富血小板血浆联合同种异体骨移植治疗Ⅰ型长骨骨缺损的临床效果观察

Clinical efficacy of platelet-rich plasma combined with allograft bone transplantation for typeⅠ long bone defect

目的探讨富血小板血浆(PRP)联合同种异体骨移植治疗Ⅰ型长骨骨缺损的疗效。方法将62例长骨骨缺损患者按随机数字表法随机分为两组,观察组32例行(PRP)+同种异体骨移植治疗,对照组30例行自体骨移植治疗。两组患者均随访12个月。比较两组患者手术时间、术中出血量、住院时间、并发症发生率、植骨成功率及骨融合率、骨融合时间。结果两组手术时间、术中出血量、住院时间、并发症发生率、植骨成功率、骨融合率、骨融合时间比较,差异均无统计学意义(均P>0.05)。结论 PRP联合同种异体骨移植治疗Ⅰ型长骨骨缺损的疗效与自体骨移植治疗相当,值得推广应用。

Objective To explore the efficacy of platelet-rich plasma（ PRP） combined with allograft bone transplantation for typeⅠlong bone defect. Methods Sixty-two patients with long bone defect were divided into two groups using the random number table method.Thirty-two cases in the observation group received PRP plus allograft bone transplantation,while 30 cases in the control group underwent autogenous bone grafting. The patients in the two groups were followed up for 12 months. The operation duration,intraoperative blood loss,hospital stay,incidence rate of complications,success rate of bone grafting,rate of bone healing,and time to bone healing were compared between the two groups. Results No statistically significant difference was found among the two groups in the operation duration,intraoperative blood loss,hospital stay,incidence rate of complications,success rate of bone grafting,rate of bone healing,or time to bone healing（ all P 0. 05）.Conclusion PRP combined with allograft bone transplantation has similar efficacy compared to autogenous bone grafting for type Ⅰ long bone defect,and it is worth of clinical application.