原发性胆汁性肝硬化患者超声评分与临床病理分期的相关性

Ultrasonographic and clinical characteristics of primary biliary cirrhosis

目的评估超声检查判断原发性胆汁性肝硬化(PBC)患者病情变化的实用性。方法相关性分析PBC患者的临床分期、病理分期和超声评分之间的相关性。结果 215例PBC患者超声评分与临床分期有相关性(r=0.326,P=0.00)。64例肝活检PBC患者不同病理分期的超声评分比较有差异(H=25.406,P=0.000),且变化趋势与病理分期一致,病理分期、超声评分与临床分期无相关性(P>0.05)。结论对于不适合或不愿进行肝活检的PBC患者,超声检查是一项无创、快捷、操作性强的判断病情变化的方法。

Objective To evaluate the usefulness of ultrasonography in judging the changes of patients with primary biliary cirrhosis（PBC）. Methods The case report form was used to collect the clinical information of the patients with PBC, and then the relationships among clinical stage, pathological stage and ultrasonographic score were analyzed. Results A total of 215 patients with PBC were collected. The male to female ratio was 1： 9.75. The mean age was（55.57 ± 10.47） y, and the duration of disease was（3.30 ± 3.19） y. There was a correlation between ultrasonographic score and clinical stage in the patients with PBC（P〈0.05）. In the 64 patients with PBC who underwent liver biopsy, there were significant differences in ultrasonographic scores among the patients different pathological grades（P〈0.05）, but clinical stage was not correlated to pathological stage or ultrasound score（P〈0.05）. Conclusions Ultrasonography is a noninvasive and highly-manipulative method of assessing disease progression in patients with PBC who are unfit or unwilling to undergo a liver biopsy.