桥本甲状腺炎自身抗体与甲状腺功能的相关性分析

Correlations between thyroid autoantibodies and thyroid function in patients with newly-diagnosed Hashimoto's thyroiditis

目的探讨初诊桥本甲状腺炎(HT)患者的抗甲状腺微粒体抗体(Tm Ab)和抗甲状腺球蛋白抗体(Tg Ab)与甲状腺功能的相关性。方法收集初诊甲状腺肿患者313例,其中HT患者132例,非HT患者181例,检测血清Tm Ab、Tg Ab、TSH、FT_3、FT_4、TT_3、TT_4及B超测定甲状腺大小,分析抗体与甲状腺功能的相关性。结果HT患者年龄低于非HT患者,TSH高于非HT患者(P<0.05);HT女性患者的TSH、Tm Ab及Tg Ab与男性患者无差异(P>0.05),但FT_3、FT_4、TT_3及TT_4低于男性(P<0.05),非HT女性患者年龄、FT_3及FT_4低于男性患者(P<0.05);HT患者中Tm Ab与TSH呈正相关(P<0.05),与FT_4呈负相关(P<0.05),Tg Ab与FT_3、FT_4及TT_4呈负相关(P<0.05)。结论初诊HT患者自身抗体和性别与甲状腺功能存在密切关系,但抗体在甲状腺损伤过程中呈现不同作用特点。

Objective To explore the relationships between Tm Ab,Tg Ab and thyroid function in the patients with newly-diagnosed Hashimoto’s thyroiditis（HT）.Mehtods The cases of goiter patients（n=313）were collected,which included HT patients（n=132）and non-HT patients（n=181）.Serum Tm Ab,Tg Ab,TSH,FT3,FT4,TT3and TT4 of each patient were detected,and the sizes of thyroid gland were recorded through ultrosonography.The correlations of Tm Ab and Tg Ab with thyroid function were analyzed.Results Compared with the non-HT group,the patients’age was younger,and the TSH level was higher in the HT group（P〈0.05）.The levels of TSH,Tm Ab and Tg Ab in the female HT patients were comparable to those in the male HT patients.However,the levels of FT3,FT4,TT3 and TT4 in the female HT patients were lower than those in the male HT patients（P〈0.05）.The levels of FT3 and FT4 in the female non-HT patients were lower than those in the male non-HT patients,and their age was younger than that in the male non-HT patients（P〈0.05）.Pearson correlation analysis showed that Tm Ab was positively correlated with TSH,and negatively correlated with FT4 in the patients with HT（P〈0.05）;Tg Ab was negatively correlated with FT3,FT4 and TT4（P〈0.05）.Conclusions In newly-diagnosed HT patients,Tm Ab,Tg Ab and gender are closely correlated with the function of thyroid and these two antibodies indicate different patterns in thyroid damage.