胶质瘤患者血清中IGF-1、GFAP的表达及意义

Expression and significance of IGF-1 and GFAP in serum of glioma patients

目的探讨血清中胰岛素生长因子-1(IGF-1)、胶质纤维酸性蛋白(GFAP)在胶质瘤患者的表达及意义。方法采用双抗体一步夹心法分别测定40例脑胶质瘤患者及30例健康者和35例其他颅内良性肿瘤患者血清中IGF-1和GFAP水平。结果健康者与其他颅内良性肿瘤患者血清中IGF-1和GFAP水平差异无统计学意义(P>0.05);胶质瘤患者血清中IGF-1和GFAP水平明显高于健康者和其他颅内良性肿瘤患者(P<0.05);胶质瘤患者血清中IGF-1和GFAP水平术后较术前降低,差异有统计学意义(P<0.05)。结论 IGF-1、GFAP在胶质瘤患者血清中表达明显高于健康者与其他颅内良性肿瘤患者,有较好的灵敏度和特异度,可作为胶质瘤患者的血清标志物,有一定的临床应用价值。

Objective To explore the expression and significance of insulin growth factor 1（IGF-1）and glial fibriuary acidic protein（GFAP）in patients with glioma.Methods The serum levels of IGF-1 and GFAP in40 glioma patients,30 healthy subjects and 35 patients with other benign intracranial tumors were measured by double antibody sandwich method.Results There was no significant difference in serum IGF-1 and GFAP levels between healthy subjects and other benign intracranial tumor patients（P〈0.05）,and the levels of IGF-1 and GFAP in the serum of glioma patients were significantly higher than those of healthy and other benign intracranial tumor patients（P〈0.05）.The serum levels of IGF-1 and GFAP in glioma patients after operation were significantly lower than those before operation（P〈0.05）.Conclusion The expression of IGF-1 and GFAP in the serum of glioma patients is significantly higher than those of healthy subjects and other benign intracranial tumor patients.It has good sensitivity and specificity.It can be used as a serum marker of glioma patients and has certain clinical value.