脑脊液清蛋白及免疫球蛋白G在神经系统炎性疾病测定中的意义

Significance of cerebrospinal fluid albumin and immunoglobulin G in the diagnosis of nervous system inflammatory diseases

目的探讨脑脊液清蛋白(CAlb)及脑脊液免疫球蛋白G(CIgG)对神经系统炎性疾病测定的意义。方法回顾性分析该院相关临床科室2016年4月至2017年3月行脑脊液检查的患者104例,按是否为炎性疾病分为炎性组59例和非炎性组45例。分别行血清清蛋白(SAlb)、CAlb和CIgG的检查,并计算清蛋白指数(QAlb),QAlb=CAlb/SAlb进行对比研究。结果做对数转换后,炎性组ln(CIgG)为4.36±1.00,ln(CAlb)为6.31±0.77,ln(QAlb)为2.57±0.79,与非炎性组[ln(CIgG)3.53±0.59,ln(CAlb)5.52±0.50,ln(QAlb)1.88±0.47]相比,差异均有统计学意义(P<0.05)。结论不同神经系统疾病,血脑屏障损害程度不同,鞘内IgG合成不同,CIgG、CAlb、QAlb能作为判断血脑屏障损害的指标,也能用于神经系统炎性和非炎性疾病的辅助诊断。CIgG的升高也可能提示疾病的发生与自身免疫性相关。

Objective To investigate the significance of cerebrospinal fluid albumin（CAlb）and cerebrospinal fluid immunoglobulin G（CIgG）in the diagnosis of nervous system inflammatory diseases.MethodsA retrospective analysis of 104 patients with cerebrospinal fluid examination from April 2016 to March 2017 in the hospital who were divided into 59 cases of inflammatory disease and 45 cases of non-inflammatory.Blood clearance protein（SAlb）,CAlb and G IgG were examined（QAlb=CAlb/SAlb）and compared.Results After logarithmic transformation,ln（CIgG）4.36±1.00,ln（CAlb）6.31±0.77,ln（QAlb）2.57±0.79 in inflammatory group,compared with non-inflammatory group,ln（CIgG）3.53±0.59,ln（CAlb）5.52±0.50,ln（QAlb）1.88±0.47,the difference,were statistically significant（P〈0.05）.Conclusion The degree of blood-brain barrier damage is different in different nervous system diseases,and the synthesis of IgG is different,CIgG,CAlb,QAlb can be used as an indicator to judge the blood-brain barrier damage,and can also be used in the differential diagnosis of inflammatory and non-inflammatory diseases of the nervous system.The increase of CIgG also suggests that the occurrence of the disease may be related to autoimmunity.