琥珀酸亚铁和右旋糖酐铁治疗缺铁性贫血的疗效对比分析

Analysis of Comparison of Curative Effect of Ferrous Succinate and Dextriferron in Treatment of Iron-deficiency Anemia

目的探讨琥珀酸亚铁和右旋糖酐铁治疗缺铁性贫血的疗效与安全性。方法方便选取2013年1月—2017年10月该院血液科收治的192例缺铁性贫血患者为研究对象,依据治疗方法分为右旋糖苷铁组(96例)和琥珀酸亚铁(96例),对比观察患者不同用药时期血红蛋白水平恢复情况,评价两组疗效,统计并发症。结果右旋糖苷铁组治疗总有效率(92.71%)与琥珀酸亚铁组(90.63%)比较差异无统计学意义(χ2=1.06,P>0.05);右旋糖苷铁组用药不良反应发生率(11.46%)与琥珀酸亚铁组(19.79%)比较差异有统计学意义(χ2=3.97,P<0.05)。结论琥珀酸亚铁和右旋糖酐铁治疗缺铁性贫血效果相当,但患者用药右旋糖酐铁能更快提高血红蛋白水平,不良反应小,依从性高,更具临床推广价值。

Objective To study the curative effect and safety of ferrous succinate and dextriferron in treatment of iron-deficiency anemia. Methods 192 cases of patients with iron-deficiency anemia admitted and treated in our hospital from January 2013 to October 2017 were convenient selected and divided into two groups with 96 cases in each according to different treatment methods, respectively treated with dextriferron and ferrous succinate, and the recovery of hemoglobin level at different medication periods of patients was observed and the curative effect of the two groups was evaluated, and the complications were counted. Results The difference in the total treatment effective rate between the dextriferron group and the ferrous succinate group were not statistically significant（92.71% vs 90.63%）（χ2=1.06, P〈0.05）, and the difference in the incidence rate of medication between the dextriferron group and the ferrous succinate group were statistically significant（11.46% vs 19.79%）,（χ2=3.97, P〈0.05）. Conclusion The effect of ferrous succinate and dextriferron in treatment of iron-deficiency anemia is similar, but the dextriferron can improve the hemoglobin level more rapidly, with small side effect and high compliance, which is of clinical promotion value.