外周血幼稚粒细胞在脓毒症严重程度以及预后评估中的作用

Effects of peripheral blood immature granulocytes in the evaluation of severity and prognosis of sepsis

目的探讨外周血幼稚粒细胞在脓毒症严重程度以及预后评估中的作用。方法选取2016年1月~2017年9月我院收治的60例脓毒症患者的血样检验结果,根据脓毒症患者肺损伤情况将患者分为高危组21例、中危组22例、低危组17例,分别对三组患者血样进行外周血幼稚粒细胞、血清降钙素原和C-反应蛋白检测,分析其不同危险程度以及预后之间的差异。结果高危组患者的外周血幼稚粒细胞、血清降钙素原和C-反应蛋白均高于中危组,低危组,差异有统计学意义(P<0.05)。死亡组患者的外周血幼稚粒细胞、血清降钙素原和C-反应蛋白明显高于存活组,差异有统计学意义(P<0.05)。结论外周血幼稚粒细胞随着脓毒症的病情加重,其数量明显增加,同时,对于患者的预后评估也具有积极的作用,建议在临床工作中推广。

Objective To investigate the effects of peripheral blood immature granulocytes in the evaluation of severity and prognosis of sepsis.Methods Blood samples of 60 patients with sepsis admitted to our hospital from January 2016 to September 2017 were selected for examination.According to the lung injury of sepsis patients,patients were divided into high-risk group（21 cases）,middle-risk group（22 cases） and low-risk group（17 cases）.Peripheral blood samples of three groups were tested for naive granulocytes,serum procalcitonin and C-reactive protein,and the differences between different risk levels and prognosis were analyzed.Results The peripheral blood naive granulocytes,serum procalcitonin and C-reactive protein of patients in high-danger group were higher than those in middle danger-risk group and low danger-risk group,the differences were statistically significant（P〈0.05）.The peripheral blood naive granulocytes,serum procalcitonin and C-reactive protein in death group were significantly higher than those in survival group,and the differences were statistically significant（P〈0.05）.Conclusion Peripheral blood immature granulocytes increase in number along with the increasing severity of sepsis.At the same time,it also has a positive effect on the prognosis evaluation for patients,which is recommended to be promoted in clinical practice.