血清肝素结合蛋白在脓毒症患者中的变化及临床意义

Serum level of Heparin binding protein of pyohemia cases and the clinical significance

目的观察脓毒症患者血清中肝素结合蛋白(HBP)水平,探讨其临床意义。方法选取2016年6月~2017年11月我院重症监护病房收治的55例脓毒症患者作为脓毒症组,选取同期在本院行体检且健康者50例作为对照组。比较两组的血清HBP、C反应蛋白(CRP)和降钙素原(PCT)水平,比较普通型和严重型脓毒症患者入院第2天的血清HBP、CRP、PCT水平,比较脓毒症存活组和死亡组入院后第2天患者的血清HBP、CRP和PCT水平。结果脓毒症患者血清HBP[(67.31±7.40)ng/ml]、CRP[(90.21±10.45)mg/l]、PCT[(15.41±2.04)ng/ml]水平显著高于对照组(P<0.01);严重脓毒症患者血清HBP[(113.13±12.67)ng/ml]、CRP[(146.96±16.12)mg/l]、PCT[(27.44±3.95)ng/ml]水平显著高于普通脓毒症患者(P<0.01);死亡组患者血清HBP[(125.65±14.33)ng/ml]、CRP[(150.35±16.78)mg/l]、PCT[(29.31±3.13)ng/ml]水平明显高于存活组(P<0.01);脓毒症患者血清HBP水平与CRP、PCT均呈显著正相关(P<0.01)。结论脓毒症患者血清HBP水平明显升高,可能是临床评价脓毒症患者病情严重程度、预后的有效指标。

Objective To observe serum level of Heparin binding protein（HBP） of cases with pyohemia and investigate the clinical significance.Methods From June 2016 to November 2017,55 cases with pyohemia from intensive care unit of my hospital were selected as pyohemia group,and 50 healthy cases were chosen as control group by physical examination.Serum levels of HBP,C-reactive protein（CRP）,and procalcitonin（PCT） of both groups were compared.Serum levels of HBP,CRP,and PCT were compared in ordinary type pyohemia and serious type pyohemia at 2 days after admitted to hospital.Serum levels of HBP,CRP,and PCT were compared in survival group and dead group of pyohemia at 2 days after admitted to hospital.Results Serum levels of HBP（[67.31±7.40] ng/ml）,CRP（[90.21±10.45] mg/l）,and PCT（[15.41±2.04] ng/ml） of pyohemia cases were evidently higher than control group（P0.01）.Serum levels of HBP（[113.13±12.67]ng/ml）,CRP（[146.96±16.12] mg/L）,and PCT（[27.44±3.95] ng/ml） of serious type pyohemia cases were obviously higher than those of ordinary type pyohemia（P〈0.01）.Serum levels of HBP（[125.65±14.33] ng/ml）,CRP（[150.35±16.78] mg/L）,and PCT（[29.31±3.13] ng/ml） of death group were obviously higher than those of survival group（P〈0.01）.Conclusion Serum level of HBP of cases with pyohemia is obviously increased,and may be one of effective indexes evaluating severity and prognosis of cases with pyohemia.