中西医治疗特发性膜性肾病的Meta分析

Meta-analysis of TCM combined with western medicine in the treatment of idiopathic membranous nephropathy

目的:评价中西医结合治疗特发性膜性肾病(IMN)的疗效是否优于单用西药疗法。方法:计算机检索Pub Meb、CNKI、万方、维普等数据库,日期为2010年1月1日-2017年10月30日,筛选为中西医结合治疗IMN的随机对照临床试验,数据采用Stata/SE 12.0软件分析。结果:最终纳入16篇文献,共877例IMN患者,试验组464例,对照组413例。Meta分析结果示:中西医结合治疗组与单纯西药组相比:(1)整体有效率(RR=1.301,95%CI:1.205-1.404,P=0.000);(2)治疗后24小时尿蛋白(SMD=-1.244,95%CI:-1.425-1.062,P=0.000);(3)治疗后血浆白蛋白(SMD=0.479,95%CI:0.298-0.661,P=0.000)。结论:中西医结合治疗特发性膜性肾病(IMN)的疗效优于单用西药治疗。

Objective： To evaluate whether the combination of Chinese and western medicine is superior to that of using western medicine alone in treating idiopathic membranous nephropathy（IMN）. Methods： The databases of Pub Meb, CNKI, Wanfang, Cqvip, etc. were searched, and all the data were from January 1, 2010 to October 30, 2017. The randomized controlled clinical trials of integrative medicine treatment for IMN were included. The data were analyzed by using Stata/SE 12.0 Software Analysis. Results： A total of 16 articles were enrolled in this study. A total of 877 patients with IMN were included, with 464 cases in the experimental group and 413 cases in the control group. The results of Meta analysis showed that the total effective rate（RR=1.301, 95% CI： 1.205-1.404, P=0.000）, urinary protein 24 hours after treatment（SMD=-1.244, 95% CI：-1.425-1.062, P=0.000） and plasma albumin after treatment（SMD=0.479, 95% CI： 0.298-0.661, P=0.000） in the integrated medicine group were better. Conclusion： The effect of the integrated medicine on idiopathic membranous nephropathy（IMN） was better than western medicine alone.