ω-3多不饱和脂肪酸补充剂对动脉硬化防治疗效的Meta分析

Meta analysis of the efficacy of ω-3 polyunsaturated fatty acid supplement on arteriosclerosis

目的系统评价ω-3多不饱和脂肪酸补充剂在防治动脉硬化中的效果。方法计算机搜索中外文数据库,检索从建库至2017年8月14日发表的相关文献。纳入口服ω-3多不饱和脂肪酸补充剂与安慰剂防治动脉硬化的试验性研究,不限定剂量和样本特征,由两位研究人员独立评价研究质量及提取资料后交叉核对,采用RevMan 5.3软件对各指标进行数据合并分析。结果纳入12项研究1325例样本,12项研究中10个为平行设计试验,2个为交叉试验。Meta分析结果显示,与安慰剂相比,口服ω-3多不饱和脂肪酸补充剂可以降低肱-踝脉搏波传导速度、C反应蛋白,差异有统计学意义（P〈0.05）;但对白细胞介素6、脂联素、瘦素的干预效果不明显,差异无统计学意义（P〉0.05）。结论口服ω-3多不饱和脂肪酸补充剂可能有降低大动脉和中动脉动脉硬化程度及改善炎症反应的作用。

Aim To evaluate systematically the efficacy of ω-3 polyunsaturated fatty acid supplement in the prevention and treatment of arteriosclerosis. Methods Chinese and foreign language databases from their establishment date to August 14 th 2017 were systematically searched for adult human clinical trials to investigate the effects of ω-3 polyunsaturated fatty acid supplements on arteriosclerosis. Experimental study of oral ω-3 polyunsaturated fatty acid supplement and placebo were included in the prevention and treatment of arteriosclerosis. No limits were set on dosage sizes or sample characteristics. The research quality and data were evaluated and cross checked by two researchers independently. Meta analysis was carried out using Rev Man 5.3 software. Results 12 studies involving 1325 people were included,including 10 parallel tests and 2 cross tests. The Meta analysis showed that the oral ω-3 polyunsaturated fatty acid supplements could reduce the brachial-ankle pulse wave velocity and the C-reactive protein compared with placebo,and the differences were statistically significant（ P〈0. 05）. However,the effects of oral ω-3 polyunsaturated fatty acid supplement on interleukin-6, adiponectin and leptin were not significant, and the differences were not statistically significant（ P〉0.05）. Conclusion Oral ω-3 polyunsaturated fatty acid supplements may have the efficacy of reducing the degree of arteriosclerosis and improving the inflammatory response in large and middle arteries.