全光学光声/OCT双模态成像系统及其应用

All-optical Photoacoustic/OCT Dual-mode Imaging System and Its Applications

本文提出了一种新型的全光学光声/OCT双模态成像系统。该系统利用同一个低相干迈克尔逊干涉仪即可实现非接触式光声成像和OCT于一体,系统装置结构简单,可同时获取生物组织的吸收与散射结构信息。通过模拟实验证明了该双模态成像系统的可行性及成像能力,并对活体小鼠耳朵同时进行光声/OCT成像测试,实验结果表明非接触式光声/OCT双模态成像系统可以实现生物组织内的微血管及散射结构的高分辨率成像。进一步地,我们将光声/OCT双模态成像系统应用于基底细胞癌的检测中,获得了初步的研究结果,表明了该系统在皮肤肿瘤诊断中的具有潜在的应用价值。

In this paper, we present a novelty- all-optical dual-mode photoacoustic and optical coherence tomography （OCT） system. The dual-mode imaging system can realize the photoacoustic imaging and by using a single Michelson interferometer, which can obtain the absorption and scattering ilfformation of the tissue. The feasibility- and capacity- of the system was demonstrated with the nfinficking experiments. In addition, in vivo experiments were conducted, the ex- perimental results prove that the dual-mode photoacoustic and optical coherence tomography system can acquire the nfi- crovasculaure and scattering structure image in tissue with high resolution. Furthermore, the dual-mode imaging system has been applied in the detection of basal cell carcinoma and acquired some experimental results, which indicate that the dual-mode imaging system has great potential to diagnose the skin tumour.