非梗阻性无精症中微小RNA的研究进展

Research progress in micro RNAs in non-obstructive azoospermia

人类精子的发生在遗传学上是一个比较复杂的细胞分化过程,受到来自多方面因素的影响,其中微小RNA(核糖核酸)发挥着重要的角色,并且信使RNA转录后的基因调控是比较显著的特征之一。人类非梗阻性无精症主要是由于男性睾丸中不产生精子而产生的一种不孕不育,在男性非梗阻性的无精症众多原因中,微小RNA的表达失控与生精功能息息相关。可见,对于微小RNA所起的作用进行探讨,可以从分子层面阐述微小RNA异常表达和调节失控与男性生殖细胞产生功能障碍的相互关联,有助于对非梗阻性的无精症的相关发病机制、初步诊断和治疗手段预后判定的深入研究。

The occurrence of human sperm in genetics is a complex process of cell differentiation affected by a variety of factors,where microRNAs play an important role,and messenger RNA transcription gene regulation is one of the most significant features. Non-obstructive azoospermia is a kind of infertility mainly caused by non-production of sperms,which is closely related to the abnormal expression of microRNA. It is very helpful to the pathogenesis,preliminary diagnosis,treatment and prognosis to explain the mechanism of the abnormal expression and regulation of microRNA from the molecular level.