中西药联合补肾疏肝,活血通络法治疗勃起功能障碍

Efficiency of Chinese joint western medicine in tonifying kidney and soothing liver,activating blood circulation and dredging collaterals for the treatment of erectile dysfunction

目的:观察以补肾疏肝,活血通络法为主治疗勃起功能障碍的临床疗效。方法:为能够获得最大的检验效能,入选的60例患者随机分为治疗组(右归胶囊加疏肝益阳胶囊联合他达拉非片)和对照组(他达拉非片)。治疗4周后,采用国际勃起功能问卷-5(IIEF-5)、勃起质量量表(EQS)、阴道内射精潜伏时间、每周性交频率、性交满意度比较两组的治疗效果。结果:治疗组治愈7例,显效15例,有效6例,无效2例,总有效率93.3%;对照组治愈2例,显效13例,有效10例,无效5例,总有效率83.3%;治疗组疗效优于对照组(P<0.05)。两组患者治疗后较治疗前IIEF-5评分、EQS评分、阴道内射精潜伏时间、每周性交频率、性交满意度均显著提高,差异具有统计学意义(P<0.01);治疗组疗效优于对照组,差异具有统计学意义(P<0.05)。结论:将他达拉非片"西为中用",认为他达拉非片性温大热,无毒,入心、肝、脾经,温阳化气,活血通络。小剂量5mg,1次/d,引药直入宗筋,可以明显提高中药辨证的疗效;大剂量兴阳启痿。配合补肾壮阳的右归胶囊,疏肝解郁的疏肝益阳胶囊,建立的以补肾疏肝,活血通络法治疗勃起功能障碍的临床疗效较优于他达拉非片。

Objective： To observe the clinical effect of therapy of tonifying kidney,soothing liver,activating blood circulation and dredging collaterals on the treatment of erectile dysfunction（ ED）. Methods： A total of 60 patients were randomly divided into treatment group（ Yougui capsules combined with Shugan Yiyang capsule combined with Tadalafil tablets） and control group（ Tadalafil tablets） to obtain the maximum test efficiency. The international erectile function questionnaire-5（ IIEF-5）,the Erection Quality Scale（ EQS）,the time of vaginal ejaculation latency,the frequency of sexual intercourse,and the satisfaction of sexual intercourse were compared between the two groups at 4 weeks after treatment. Results： 7 cases were cured,15 cases were markedly effective,6 cases were effective and 2 cases were ineffective in the treatment group,a total effective rate of 93. 3%. 2 cases were cured,13 cases were markedly effective,10 cases were effective and 2 cases were ineffective in the control group,a total effective rate of 83. 3%. The curative effect of the treatment group was better than that of the control group（ P〈0. 05）. The scores of IIEF-5,EQS,vaginal ejaculation,latency,frequency of sexual intercourse and sexual intercourse satisfaction in the two groups after treatment were significantly higher than those before treatment（ P〈0. 01）,more significant in the treatment group than the control group（ P〈0. 05）. Conclusions： The Tadalafil tablets is warm and hot in nature,non-toxic that enriches the heart,liver and spleen passes,and activates blood circulation and dredges collaterals. Combined with Yougui capsule and Shugan Yiyang capsule,its curative effect in the treatment of ED is better than using alone.