PPR蛋白调控植物细胞器RNA加工的分子功能

The Roles of PPR Proteins on Plant Organelle RNA Processing

35肽重复(pentatricopeptide repeat,PPR)蛋白是2000年发现的一类由多个重复单位串联而成的核编码蛋白质。PPR蛋白广泛存在于真核生物中,在陆生植物中尤为普遍。PPR蛋白大多定位于线粒体或叶绿体。多项研究表明,PPR蛋白为序列特异性RNA结合蛋白质,在细胞器RNA编辑、剪接、稳定、切割及翻译等转录后加工过程发挥重要作用。PPR蛋白功能缺陷会导致植物生长发育异常,甚至胚胎致死。本文主要就PPR蛋白功能及作用机制进行综述,并对尚待解决的问题及研究前景加以探讨,以期为PPR蛋白的深入研究提供思路。

Pentatricopeptide repeat（ PPR） proteins,which were identified in 2000 are nucleus coding proteins that compose of multiple tandem repeats. PPR proteins are widely found in eukaryotes and particularly prevalent in terrestrial plants. Most of them target to mitochondria or chloroplasts where they participate in post-transcriptional processes including RNA editing,splicing,stability,cleavage and translation by binding to specific RNA sequences. Functional defects of PPR proteins will lead to abnormal growth of plants,even death of embryo lethal. This review summarizes the function and molecular mechanism of PPR proteins,and discusses the challenge and prospects of PPR research,which will provide clues for further understanding of the roles of PPR proteins.