葛根四虫汤联合硫酸氨基葡萄糖治疗颈椎病对颈髓功能评分的影响研究

Effect of Using Gegen Sichong Decoction Combined with Glucosamine Sulfate in the Treatment of Cervical Spondylosis on Cervical Spinal Function Score

目的:观察葛根四虫汤联合硫酸氨基葡萄糖治疗颈椎病的临床疗效及其对患者颈髓功能评分、血流动力学的影响。方法:按随机数字表法将138名颈椎病患者分为对照组和观察组,每组69例。对照组予以硫酸氨基葡萄糖治疗,观察组在对照组基础上联合葛根四虫汤治疗。观察两组患者临床疗效、中医症状及安全性,评价治疗前后患者颈髓功能,测定治疗前后患者右侧椎动脉(RVA)、左侧椎动脉(LVA)、基底动脉(BA)的收缩期峰流速(Vs)、平均流速(Vm)。结果:观察组有效率显著高于对照组(P<0.05);治疗后两组患者中医症状评分显著下降(P<0.05),颈髓功能评分显著升高(P<0.05),治疗后观察组中医症状及颈髓功能显著优于对照组(P<0.05);治疗后两组患者RVA、LVA和BA的Vs、Vm值显著增加(P<0.05),治疗后组间差异显著(P<0.05)。两组患者治疗期间均无严重不良反应。结论:葛根四虫汤联合硫酸氨基葡萄糖治疗颈椎病患者疗效显著,可有效改善患者中医症状,提高患者颈髓功能,缓解患者临床症状。

Objective： To explore the clinical curative effect of Gegen Sichong Decoction combined with glucosamine sulfate in the treatment of cervical spondylosis and the effect on cervical spinal function score and hemodynamics. Methods： 138 patients with cervical spondylosis were divided into controlled group and observation group by the random number table method,with69 cases in each group. The controlled group was treated with glucosamine sulfate,and the observation group was treated with Gegen Sichong Decoction combined with glucosamine sulfate. The clinical curative effect,TCM symptoms and safety in the two groups were observed. The cervical spinal function was evaluated before and after treatment. The peak systolic velocity（ Vs） and mean velocity（ Vm） of the right vertebral artery（ RVA）,left vertebral artery（ LVA） and basilar artery（ BA） were measured before and after treatment. Results： The effective rate in the observation group was significantly higher than that in the controlled group（ P〈0. 05）. After treatment,the TCM symptom scores of the two groups were decreased significantly（ P〈0. 05）,and the cervical spinal function scores were increased significantly（ P〈0. 05）. After treatment,the TCM symptoms and cervical spinal function in the observation group were significantly better than those in the controlled group（ P〈0. 05）. After treatment,the Vs and Vm of RVA,LVA and BA in the two groups were significantly increased（ P〈0. 05）,with significant differences between groups（ P〈0. 05）. There was no serious adverse reaction in the two groups during the treatment. Conclusion： Gegen Sichong Decoction combined with glucosamine sulfate is effective in treating cervical spondylosis. It can effectively improve TCM symptoms and cervical spinal function and relieve clinical symptoms.