清热除湿解毒汤加减在肺胃湿热型痤疮中的应用研究

Study on the Application of Modified Qingre Chushi Jiedu Decoction for Pulmonary and Gastric Damp Heat Type Acne

目的:观察中医辨证论治在肺胃湿热型痤疮中的应用效果。方法:选取2015年6月至2016年6月期间我院就诊的120例肺胃湿热型痤疮患者作为研究对象,应用随机数表法分为对照组和观察组,各60例。对照组应用四环素片+克林霉素凝胶+维A酸乳膏进行治疗,观察组在常规应用克林霉素凝胶+维A酸乳膏同时加用清热除湿解毒汤加减治疗。治疗后评估临床疗效,观察比较两组患者的皮肤状态改善情况及药物安全性,并常规随访至治疗后2个月内,观察统计复发情况。结果:观察组治疗总有效率90.00%(54/60)高于对照组的71.67%(43/60),差异有统计学意义(P<0.05);观察组治疗后脸部皮肤p H、油脂程度低于对照组,皮肤水分含量高于对照组,差异有统计学意义(P<0.05);治疗期间,观察组不良反应总发生率5.00%(3/60)低于对照组的18.33%(11/60),差异有统计学意义(P<0.05);治疗后2个月,观察组复发5例(8.33%),对照组复发15例(25.00%),两组复发率对比采用有统计学意义(χ2=6.752,P=0.014)。结论:在肺胃湿热型痤疮患者常规治疗基础上进行中医辨证论治疗效显著,安全性高,可加速临床症状缓解,改善皮肤状态,降低复发率。

Objective： To study the effect of TCM syndrome differentiation and treatment in lung and stomach damp heat type acne. Methods： 120 cases of patients with hot and humid acne vulgaris were enrolled in this study from June 2015 to June 2016. All the patients were randomized to controlled group and experimental group,each group of 60 cases. The patients in the controlled group were treated with azithromycin＋clindamycin gel＋vitamin A acid cream,and patients in the observation group were treated with Modified Qingre Chushi Jiedu Decoction on the basis of routine treatment in the controlled group. After treatment to assess the clinical efficacy and follow-up to 2 months,the improvement of skin condition and drug safety was observed in both groups,and the statistical recurrence was observed. Results： The total effective rate was 90. 00%（ 54/60） in the observation group and71. 67%（ 43/60） in the controlled group,the difference was statistically significant（ P〈0. 05）. The skin p H and fat level of the facial skin in the observation group were lower than those in the controlled group,and the moisture content of the skin was higher than that of the controlled group. The difference was statistically significant（ P〈0. 05）. The incidence of adverse reactions in the observation group was 5. 00%（ 3/60） lower than that in the controlled group（ 18. 33%,11/60）,the difference was statistically significant（ P〈0. 05）. At 2 months after treatment,5 cases（ 8. 33%） were relapsed in the observation group and 15 cases（ 25. 00%） in the controlled group. The recurrence rate of the two groups was statistically significant（ χ2= 6. 752,P = 0. 014）.Conclusion： Pulmonary and stomach damp-heat acne patients on the basis of conventional treatment based on traditional Chinese medicine treatment of significant treatment,high safety,can speed up clinical symptoms,improve skin condition,reduce the recurrence rate.