新型含取代噁二唑结构的吡唑肟类化合物的合成与生物活性研究

Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Oxadiazole Moiety

为了寻找具有较好生物活性的吡唑肟类衍生物,采用活性基团拼接方法,设计合成了一系列新型含取代噁二唑结构的吡唑肟类化合物.利用~1H NMR、^(13)C NMR和元素分析等手段确证了目标化合物的结构.初步的生物活性测试结果表明,部分目标化合物显示出较好的杀虫活性.当测试浓度降为100μg/m L时,3个化合物对粘虫仍具有较好的杀虫效果,杀死率分别为70%,60%和70%.另外,1个化合物在测试浓度为500μg/m L时对蚜虫也表现出一定的杀虫作用,杀死率为60%.

In order to find novel pyrazole oximes with good bioactivities, a series of novel pyrazole oxime derivatives containing substituted oxadiazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by ^1H NMR, ^13C NMR and elemental analysis. Preliminary bioassay data indicated that some title compounds showed good insecticidal activities. At the concentration of 500 μg/mL, 9 compounds possessed insecticidal activity against Oriental armyworm with 80%~100%. When the concentration was lowered to 100 μg/mL, 3 compounds still displayed significant insecticidal activity against Oriental armyworm with 70%, 60% and 70%. Additionally, one compound had 60% insecticidal activity against Aphis medicaginis at 500 μg/mL.