摘要
在Pd/O_2体系中,邻炔基苯乙烯类衍生物经过氯钯化/Heck偶联多步串联反应,获得了13个3位氯取代茚类化合物.该方法以氧气为唯一氧化剂,以氯化锂为氯源,避免了过量氯化铜的加入,具有绿色环保、条件温和、产率高和底物普适性较好等特点.
An economic and environmental synthestic method for 3-chloroindenes from o-（alkynyl）styrenes through tandem reactions including choropalladation/Heck cross coupling in Pd/O2 system was reported. Taking green dioxygen as sole oxidant and LiCl as chlorine source, 13 functionalized 3-chloroindenes could be synthesized in moderate to high yield without the addition of CuCl2.
作者
邱会华
成博睿
黄颖思
陈翠
周鹏
Qiu Huihua;Cheng Borui;Huang Yingsi;Chen Cui;Zhou Peng(School of Chemical Engineering,Guangdong University of Petrochemical Technology,Maoming 52500)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第7期1817-1822,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21602035)
广东省自然科学基金(No.2016A030307030)资助项目~~
关键词
钯催化
氧气
氯钯化
茚
Pd-catalyzed
dioxygen
chloropalladation
indene
