oXiris-内毒素吸附技术的临床应用

oXiris-Clinical practice of endotoxin adsorption

脓毒症是宿主对感染的反应失调,产生危及生命的器官损害;是重症监护病房患者死亡的主要原因。内毒素作为触发体内瀑布式炎症级联反应的源头,引起大量促炎及抗炎因子释放,在脓毒症的发病中起重要作用。因此,目前认为清除内毒素是改善脓毒症预后的有效手段。目前多黏菌素B吸附柱(PMX)和吸附性血滤膜(o Xiris)均能吸附内毒素。该文总结了现有的体外实验、动物实验和临床试验,认为部分脓毒症患者可通过清除内毒素获益,同时根据临床专家使用o Xiris的经验对o Xiris的临床应用提出建议。

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection, and is the leading cause of death in intensive care unit patients due to limited therapies currently. As is known to all, endotoxin is important in the pathogenesis of sepsis, whereby infection triggers a systemic inflammatory response, resulting in release of pro-and anti-inflammatory cytokines, which are thought to be responsible for the tissue damage that occurs in sepsis patients. Therefore, removing endotoxins is considered as an effective way to improve the conditions of sepsis patients.Both Toraymaxin（PMX） and adsorptive membrane such as o Xiris can remove endotoxins by adsorption, and in this review we will summarize current studies, included in vitro study, animal study, and clinical research to show the benefit from endotoxin removal by o Xiris, and also give some suggestions about o Xiris clinical practice from experienced experts.