维生素D联合胸腺五肽对慢阻肺急性加重期患者肺功能、血气指标及6min步行距离的影响

Influences of Vitamin D combined with thymopentin in lung function,blood gas analysis and 6min walking distance of patients with acute chronic obstructive pulmonary disease

目的探讨维生素D联合胸腺五肽对慢性阻塞性肺疾病(慢阻肺)急性加重期患者肺功能、血气指标及6 min步行距离的影响。方法选取慢阻肺急性加重期患者80例,依据随机数字表法将患者分为维生素D联合胸腺五肽治疗组(联合治疗组,n=40)和单用维生素D治疗组(单独治疗组,n=40)。对2组患者的肺功能指标、血气指标、6 min步行距离、急性加重次数及住院时间进行统计分析。结果联合治疗组患者FEV1.0、FEV1.0%预计值、FEV1.0/FVC均显著高于单独治疗组(P<0.05),PaO_2显著高于单独治疗组(P<0.05),PaCO_2显著低于单独治疗组(P<0.05);6 min步行距离为(404.6±56.6)m,显著长于单独治疗组的(357.7±45.8)m(P<0.05);急性加重次数为(0.9±0.8)次,显著少于单独治疗组的(2.0±1.1)次(P<0.05);住院时间为(11.3±3.2)d,显著短于单独治疗组的(15.6±3.0)d(P<0.05)。结论维生素D联合胸腺五肽能够有效改善慢阻肺急性加重期患者的肺功能和血气分析,延长患者6 min步行距离。

Objective To investigate the influences of Vitamin D combined with thymopentin in lung function,blood gas analysis and 6 min walking distance of patients with acute chronic obstructive pulmonary disease. Methods 80 cases of patients with acute chronic obstructive pulmonary disease who were treated from May 2014 to May 2016 were selected. These patients were divided into vitamin D combined with thymopentin treatment group（combined treatment group,n = 40） and vitamin D therapy alone group（monotherapy group,n = 40）. The lung functions,blood gas analysis,6 min walking distances,acute exacerbations and hospital stay of the two groups were statistically analyzed. Results The FEV1. 0,FEV1. 0% predicted,FEV1. 0/FVC of the combined treatment group were significantly higher in the combined treatment group（P〈0.05）,the PaO2 was significantly higher（P〈0.05）,the PaCO2 was significantly lower（P〈0.05）,the 6 min walking distance（404. 6 ± 56. 6） m was significantly longer than the monotherapy group（357. 7 ± 45. 8）m,P〈0.05）,the frequency of acute exacerbation times（0. 9 ± 0. 8） were significantly less than the monotherapy group（2 ± 1. 1）times,P〈0.05）,the hospitalization time（11. 3 ± 3. 2） d was significantly shorter than the monotherapy group（15. 6 ± 3. 0） d,P〈0.05. Conclusion Vitamin D combined with thymopentin can improve lung function and blood gas analysis and prolong 6 min walking distance of patients with acute chronic obstructive pulmonary disease.