儿童细菌性肺炎血清降钙素原及超敏crp的检测意义

The significance of serum calcitonin and hypersensitivity CRP in children with bacterial pneumonia

目的探讨儿童细菌性肺炎血清降钙素原(PCT)及超敏C-反应蛋白(hs-CRP)的检测意义。方法选取我院2011年8月至2017年8月收治的儿童细菌性肺炎患者40例作为研究组。分别采用双抗体夹心酶联免疫吸附法及免疫荧光快速定量测试技术检测两组血清PCT及hs-CRP水平,采用受试者工作特征曲线(ROC曲线)计算血清降钙素原联合超敏crp诊断细菌性肺炎的敏感度及特异度,评价PCT和CRP单项和联合检测对细菌性肺炎的诊断价值。结果研究组治疗后患儿血清降钙素原(PCT)及超敏C-反应蛋白(hs-CRP)水平明显低于治疗前(P<0.05);检测hs-CRP诊断小儿细菌性肺炎的准确率为86.25%(69/80),敏感性为80.00%(32/40),特异性为92.50%(37/40),阳性预测值为91.42%(32/35),阴性预测值为82.22%(37/45);检测PCT诊断小儿细菌性肺炎的准确率为86.25%(69/80),敏感性为82.50%(33/40),特异性为90.00%(36/40),阳性预测值为89.18%(33/37),阴性预测值为83.72%(36/43)。联合检测hs-CRP及PCT诊断小儿细菌性肺炎的准确率为93.75%(75/80),敏感性为95.00%(38/40),特异性为92.50%(37/40),阳性预测值为92.68%(38/41),阴性预测值为94.87%(37/39)。结论联合检测血清降钙素原及超敏crp对儿童细菌性肺炎的诊断敏感度及特异度均优于单项检测,两者联合检测对儿童细菌性肺炎的诊断、治疗及预后判断均具有重要意义。

Objective To investigate the significance of the detection of serum calcitonin（PCT） and hypersensitive Creactive protein（hs-CRP） in children with bacterial pneumonia.Methods 40 cases of children with bacterial pneumonia in our hospital from August 2011 to August 2017 were selected as the study group.The serum levels of PCT and hs-CRP were detected by double antibody sandwich enzyme-linked immunosorbent assay（ELISA） and fast immunofluorescence quantitative test（hs-CRP） in two groups.Using the receiver operating characteristic curve（ROC curve） to compute the sensitivity of serum procalcitonin combined with hypersensitive CRP in the diagnosis of bacterial pneumonia and specificity, evaluate the value of PCT and CRP single and combined detection in diagnosis of bacterial pneumonia.Results The level of serum calcitonin（PCT） and hypersensitivity C-reactive protein（hs-CRP） in the study group was significantly lower than that before treatment（P〈0.05）.The accuracy rate of detecting hs-CRP in children with bacterial pneumonia is 86.25 %（69/80）, the sensitivity is 80 %（32/40）, the specificity is 92.50 %（37/40）, the positive predictive value is 91.42 %（32/35）, and the negative predictive value is 82.22 %（37/45）.The accuracy rate of detecting PCT in children with bacterial pneumonia is 86.25 %（69/80）, the sensitivity is 82.50 %（33/40）, the specificity is 90 %（36/40）, the positive predictive value is 89.18 %（33/37）, and the negative predictive value is 83.72%（36/43）.The accuracy rate of combined detection of hs-CRP and PCT in diagnosing bacterial pneumonia in children is 93.75 %（75/80）, the sensitivity is 95.00 %（38/40）, the specificity is 92.50 %（37/40）, the positive predictive value is92.68 %（38/41）, and the negative predictive value is 94.87 %（37/39）.Conclusion The sensitivity and specificity of combined detection of serum procalcitonin and hypersensitivity CRP in children with bacterial pneumonia is better than single detection. Combined detection is of great significance for the diagnosis, treatment and prognosis of bacterial pneumonia in children.