埃索美拉唑治疗消化性溃疡的临床疗效评估

Evaluation on Clinical Curative Effect of Esomeprazole in Treatment of Peptic Ulcer

目的消化性溃疡患者通过埃索美拉唑来治疗,所取得的效果,加以分析。方法随机抽取从2014年1月—2016年1月在该院就诊的100例消化性溃疡患者,把他们作为研究对象,然后均匀分成两组,一组为试验组,一组为对照组,每组各有50例,两组患者均使用阿莫西林,克拉霉素来进行治疗,试验组患者在这基础上外加埃索美拉唑联合进行治疗,对照组患者在这个基础上外加奥美拉唑联合进行治疗,用药之后,对比两组之间的临床治疗效果以及患者的症状积分。结果在接受治疗之后,试验组患者的病情没有好转的有2例,占4%,总有效率为96%,对照组患者的病情没有好转的有8例,占16%,总有效率为84%,试验组患者与对照组患者的总有效率对比,前者比后者明显要高,差异有统计学意义(χ~2=14.268 1,P<0.05);对照组患者在用药后,症状积分在第一周、第三周、第六周分别为(4.0±0.9)分、(3.3±1.1)分、(2.5±1.0)分;试验组患者在用药后,症状积分在第一周、第三周、第六周分别为(3.6±1.0)分、(2.0±0.6)分、(1.1±0.6)分,试验组患者的症状积分对比对照组患者明显要低,差异有统计学意义(t=4.013、8.256、9.936、9.512,P<0.05)。结论在常规用药中加入埃索美拉唑来治疗消化性溃疡,可以提高总有效率,提升临床治疗效果,降低病症积分,值得在临床上得到广泛推广和应用。

Objective To analyze the clinical curative effect of esomeprazole in treatment of peptic ulcer. Methods 100 cases of peptic ulcer patients diagnosed in our hospital from January 2014 to January 2016 were randomly selected and divided into two groups with 50 cases in each, both groups were treated with amoxicillin and clarithromycin, the test group used the esomeprazole on that basis, while the control group were treated with omeprazole on the basis of the test group, and the clinical treatment effect and symptoms integrals of patients were compared between the two groups after medication. Results After treatment, 2 cases were not improved in the test group, accounting for 4%, and the total treatment effective rate was 96%, and 8 cases were not improved, accounting for 16%, and the total effective rate was84%, and the total effective rate in the test group was obviously higher than that in the control group, and the differences were statistically significant（χ2=14.268 1,P〈0.05）, after medication, the symptoms integrals in the first week,third week, and sixth week in the control group were obviously lower than those in the control group [（4.0 ±0.9）points,（3.3±1.1）points,（2.5±1.0）points vs（3.6±1.0）points,（2.0±0.6）points,（1.1±0.6）points], and the differences between groups were statistically significant,（t= 4.013,8.256,9.936,9.512,P〈0.05）. Conclusion The esomeprazole in treatment of peptic ulcer on the basis of theroutine drugs can improve the total effective rate, improve the clinical treatment effect and reduce the disease integrals, and it is worth wide promotion and application in clinic.