依达拉奉在以氯吡格雷为基础治疗急性脑梗中的作用

Clinical effect of edaravone in the treatment of acute cerebral infarction on the basis of clopidogrel

目的观察依达拉奉在以氯吡格雷为基础治疗急性脑梗的方案中的作用。方法选取我院2016年1月至2017年5月收治的83例急性脑梗患者作为研究对象,按照随机数字表法将其分为对照组(n=41)与观察组(n=42)。对照组单用氯吡格雷,观察组在对照组的用药基础上加用依达拉奉联合治疗,对比两组治疗效果及凝血功能。结果治疗后,两组患者的NIHSS评分较治疗前降低,且观察组低于对照组(P<0.05);观察组m RS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的血浆比黏度、全血高切黏度、纤维蛋白原、血细胞容积均优于治疗前与对照组(P<0.05)。结论依达拉奉联合氯吡格雷治疗急性脑梗患者疗效显著,能有效改善患者神经功能缺损及凝血功能,提高其生活质量,值得推广应用。

Objective To discuss the clinical effect of edaravone in the treatment of acute cerebral infarction on the basis of clopidogrel. Methods A total of 83 patients with acute cerebral infarction treated in our hospital from January 2016 to May 2017 were selected as the research objects and randomly divided into control group（41 cases） and observation group（42 cases）. The control group took the clopidogrel, and the observation group took the edaravone based on the control group. The clinical effects and coagulation function in the two groups were compared. Results After treatment, the NIHSS scores in the two groups decreased, and the NIHSS score in the observation group was lower than the control group（P〈0.05）.The m RS score in the observation group was lower than that in the control group（P〈0.05）. The levels of plasma specific viscosity, whole blood viscosity of high shear, fibrinogen and blood cell volume in the observation group were better than those before treatment and the control group（P〈0.05）. Conclusion The combination of edaravone and clopidogrel has an obvious effect in patients with acute cerebral infarction. It can greatly improve the neurologic function, coagulation function and quality of life, which is worthy of application and promotion.