西那卡塞联合骨化三醇治疗尿毒症患者继发性甲状旁腺功能亢进的效果

Effect of cinacalcet combined with ossification triol on secondary hyperparathyroidism in patients with uremia

目的探讨西那卡塞联合骨化三醇治疗尿毒症患者继发性甲状旁腺功能亢进的临床效果。方法研究时间为2015年1月至2018年1月,研究对象为于我院就诊的100例尿毒症继发性甲状旁腺功能亢进患者,随机分为对照组和观察组,每组50例。对照组采用骨化三醇治疗,观察组采用西那卡塞联合骨化三醇治疗,比较两组的临床疗效、甲状旁腺素水平、甲状旁腺体积、肾功能指标、血钙水平、血磷水平、不良反应发生情况。结果观察组的治疗总有效率高于对照组(P<0.05);治疗后,两组甲状旁腺素水平、甲状旁腺体积、血钙和血磷水平均降低,且观察组低于对照组(P<0.05);两组的不良反应总发生率、治疗前、后肾功能指标(尿素氮、血肌酐)无显著性差异(P>0.05)。结论采用西那卡塞联合骨化三醇治疗尿毒症继发性甲状旁腺功能亢进患者切实有效,可促进患者甲状旁腺素水平、甲状旁腺体积恢复,且不会对患者残余肾功能产生影响,安全可靠。

Objective To investigate the clinical effect of cinacalcet combined with ossification triol in the treatment of secondary hyperparathyroidism in uremic patients. Methods From January 2015 to January 2018, 100 uremic patients with secondary hyperparathyroidism were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with ossification triol, the observation group was treated with cinacalcet and ossification triol. The clinical efficacy, parathyroid hormone level, parathyroid volume, renal function index, blood calcium level, blood phosphorus level and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group（P〈0.05）. After treatment, the levels of parathyroid hormone,parathyroid volume, blood calcium level, blood phosphorus level in the two groups decreased, those in the observation group were lower than the control group（P〈0.05）. There were no significant differences in the total incidence of adverse reactions,renal function index（urea nitrogen, serum creatinine） before and after treatment between the two groups（P〉0.05）. Conclusion It is effective to treat uremia patients with secondary hyperparathyroidism with cinacalcet combined with ossification triol,which can promote the restoring of parathyroid hormone level and the volume of parathyroid gland. It has no effect on residual renal function and is safe and reliable.