溃疡性结肠炎发病机制免疫因素的研究进展

Research Progress of Immune Factors in the Pathogenesis of Ulcerative Colitis

溃疡性结肠炎(ulcerative colitis,UC)是一种病因未明的慢性非特异性结肠炎症性疾病,是炎症性肠病(inflammatory bow-el disease,IBD)的一种,其发病率呈上升趋势,且目前尚没有特异性的诊断试验,该病已经成为消化系统常见疾病和慢性腹泻的主要原因。大量的流行病学证据显示免疫异常与溃疡性结肠炎的发病相关。该文就UC发病的各种免疫影响因素予以综述。

Ulcerative colitis is a chronic nonspecific inflammatory disease of the intestinal tract of unknown cause,which belongs to the inflammatory bowel disease（IBD）.The morbidity of the disease has increased in recent years and there is no specific diagnostic test, the disease has become the main reason for the common digestive system disease and chronic diarrhea. A large number of epidemiological evidence shows that immune abnormalities are associated with the incidence of ulcerative colitis. This article reviews various immunological factors about the etiology of ulcerative colitis.