麻杏石甘汤对儿童肺炎支原体肺炎血清IL-17、TNF-α的影响

Effect of Maxing Shigan decoction on the IL-17 and TNF-α in children with mycoplasma pneumoniae pneumonia

[目的]观察麻杏石甘汤治疗儿童肺炎支原体肺炎(MPP)的临床疗效及其对白介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)的影响。[方法]通过将61例符合研究纳入标准的肺炎支原体肺炎患儿随机分为治疗组和对照组,两组患者均给予阿奇霉素静脉输液治疗5 d、治疗组加用麻杏石甘汤口服7 d,分别对两组的综合疗效、治疗前后IL-17、TNF-α变化进行比较,进行麻杏石甘汤治疗儿童MPP疗效和对IL-17、TNF-α影响的评价。[结果]治疗组31例,愈显率67.7%,总有效率为96.8%;对照组30例,愈显率36.7%,总有效率为90%,治疗组临床疗效优于对照组(P<0.05)。两组患儿血清IL-17、TNF-α治疗后较治疗前均降低,治疗前后两组比较差异具有统计学意义(P<0.05);在治疗后,治疗组血清IL-17、TNF-α较对照组降低明显,治疗组与对照组比较差异具有统计学意义(P<0.05)。[结论]麻杏石甘汤治疗儿童MPP疗效显著,对IL-17、TNF-α具有免疫调节作用,值得进一步深入研究。

[Objective] To observe the clinical efficacy for the treatment of mycoplasma pneumoniae pneumonia（MPP） children and the effect on myocardial enzymes by Maxing Shigan decoction（MXSGD）. [Methods] The 61 patients were randomly divided into the treatment group and the control group. Two groups of patients were treated with intravenous infusion of azithromycin therapy for five days,treatment group was treated with MXSGD orally 7 days.Comprehensive efficacy and the myocardial enzyme values before and after treatment were compared between the two group to evaluate the clinical efficacy of MXSGD. [Results] The markedly effective rate of patients between treatment group and control group was respectively 67.7% and 36.7%,whereas, the total effective rate of patients between two groups was respectively 96.8% and 90.0%,there was significant difference between the two groups（P〈0.05）. The clinical symptoms of patients recovered significantly better in treatment group than in control group. In addition, compared with those in control group, patients in treatment group had fewer the side effects of medicine. The levels of IL-17 and TNF-α in children with MP pneumonia between two group were significantly lower after treatment than before treatment, there was significant difference（ P〈0.05）. Furthermore, compared with those in control group, the levels of IL-17 and TNF-α in treatment group were significantly lower, there was significant difference between the two groups（P〈0.05）. [Conclusion] MXSGD combined with Western medicine can improve clinical symptoms and increase the total effective rate and cure rate of the children with MP pneumonia. In addition, MXSGD showed immunomodulating effect on IL-17 and TNF-α.