脉络舒通颗粒联合西药对血栓性浅静脉炎患者的临床疗效

The combinative therapeutic effects of Mailuo Shutong Granules and synthetic medications on patients with superficial thrombophlebitis

目的观察脉络舒通颗粒联合西药对血栓性浅静脉炎(STP)患者的临床疗效。方法将70例患者随机均分为对照组和观察组,对照组给予常规治疗,观察组在常规治疗基础上给予脉络舒通颗粒,2周为一个疗程。然后,比较两组治疗前后主要临床症状体征评分、内皮功能指标(NO、ET-1、TXB2、6-Keto-PGF1α、VEGF、vWF)、血液流变学指标(血浆黏度、血沉、红细胞聚集指数、纤维蛋白)。结果观察组总有效率显著高于对照组(P<0.05)。治疗后,两组主要临床症状体征评分、TXB2、ET-1、vWF、血浆黏度、血沉、红细胞聚集指数、纤维蛋白显著降低,6-Keto-PGF1α、VEGF、NO显著升高(P<0.05),观察组更明显(P<0.05)。观察组、对照组不良反应发生率分别为8.57%、14.29%。结论脉络舒通颗粒联合西药可有效缓解STP患者主要临床症状,保护血管内皮细胞,改善细胞分泌功能及血液流变学指标。

AIM To observe the combinative therapeutic effects of Mailuo Shutong Granules and routine synthetic medications on patients with superficial thrombophlebitis（ STP）. METHODS Seventy patients randomly and equally divided into control group and observation group were subjected to a two-week conventional treatment and a two-week intervention of Mailuo Shutong Granules on the basis of routine treatment,respectively,and they had the before and after the treatment assessment in terms of main clinical symptoms and signs,endothelial function indices（ NO,ET-1,TXB2,6-Keto-PGF1α,VEGF,vWF）,hemorheology indices（ plasma viscosity,blood sedimentation,erythrocyte aggregation index,fibrous protein）. RESULTS The observation group generally demonstrated significantly higher effective rate than the control group（ P〈0. 05）. Markedly decreased post-treatment scores for main clinical symptoms and signs,TXB2,ET-1,vWF,plasma viscosity,blood sedimentation,erythrocyte aggregation index,fibrous protein,and increased 6-Keto-PGF1α,VEGF and NO（ P〈0. 05） in both groups were observed,as well as the between-group variance showing the observation group＇s priority（ P〈0. 05）. The respective 8. 57% and 14. 29% incidence rates of adverse reactions in the observation group and control group were also noticed. CONCLUSION For patients with STP,a combination therapy of Mailuo Shutong Granules on the basis of synthetic medications contributes to an effective main clinical symptoms alleviation due to its vascular endothelial cells protection,cellular secretion function and hemorheological improvement.