早期宫颈癌前哨淋巴结检测的研究进展

Research Advances in the Detection of Sentinel Lymph Nodes in Early Cervical Cancer

盆腔淋巴结转移是早期宫颈癌患者预后的独立危险因素。前哨淋巴结是肿瘤区域淋巴引流的第一站,也是淋巴转移最可能发生的部位。前哨淋巴结活检术可反映盆腔淋巴结的转移状况,使大多数早期宫颈癌患者避免不必要的盆腔淋巴结清扫术,减少术后并发症发生,提高生存质量。目前已应用于早期宫颈癌临床治疗中,但如何提高病理检测微转移的准确性,改善前哨淋巴结示踪方法以及提高前哨淋巴结检出率、敏感性,降低假阴性率应进一步研究。

Pelvic lymph node metastasis is an independent risk factor for the prognosis of early cervical cancer patients.Sentinel lymph node is the first leg of the lymphatic drainage of the tumor area,which is also the most likely site of lymph node metastases. Sentinel lymph node biopsy can reflect the status of the transfer of pelvic lymph nodes,and avoid unnecessary pelvic lymph node cleaning,reduce the postoperative complications and improve the quality of life for most cervical cancer patients. It has been applied to treat the early cervical cancer,but how to improve the accuracy of pathological detection of micrometastases,improve sentinel lymph node tracer method and sentinel lymph node detection rate,sensitivity and reduce the false negative rate still needs further studies.