重型颅脑损伤患者颅内压与神经元特异性烯醇化酶、C-反应蛋白及D-二聚体水平变化关系研究

Study on the relationship between intracranial pressure and NSE,CRP and D-dimer in patients with severe craniocerebral injury

探讨重型颅脑损伤患者颅内压改变与神经元特异性烯醇化酶、C-反应蛋白和D-二聚体的关系。采用电化学发光免疫分析法检测两组血清神经元特异性烯醇化酶,免疫比浊法检测C-反应蛋白和D-二聚体水平。重型颅脑损伤患者神经元特异性烯醇化酶、C-反应蛋白和D-二聚体指标的水平均显著高于健康者,监测颅内压重度增高组患者的神经元特异性烯醇化酶、C-反应蛋白和D-二聚体水平均显著高于中度增高组。结果说明,重型颅脑损伤患者颅内压改变与患者血清中神经元特异性烯醇化酶、C-反应蛋白和D-二聚体指标水平存在明显的正相关性。

To investigate the relationship between the intracranial pressure and neuron specific enolase（ NSE）,C-reactive protein（ CRP） and D-dimer levels in patients with severe craniocerebral injury. Two groups of serum NSE were detected by electrochemiluminescence immunoassay,and immuno turbidimetry was used to detect the level of NSE,CRP and Ddimerr. The levels of,CRP protein and D-dimerr were significantly higher in patients with severe craniocerebral injury than in healthy subjects,the levels of NSE,CRP and D-dimerr in patients with severe intracranial hypertension were significantly higher than those in the moderate increase group. There is a positive correlation between intracranial pressure and serum levels of neuron specific enolase,C-reactive protein and D-two dimer in patients with severe craniocerebral injury.