硫酸镁联合丹参注射液治疗对早发型子痫前期患者NT-proBNP和炎性细胞因子水平的影响

Effects of Treatment of Magnesium Sulfate Combined with Danshen Injection on the Levels of NT-proBNP and Inflammatory Cytokines in Patients with Early-Onset Preeclampsia

目的探讨硫酸镁联合丹参注射液治疗对早发型子痫前期患者NT-pro BNP和炎性细胞因子水平的影响。方法选取早发型子痫前期患者100例,随机分为两组各50例。对照组给予硫酸镁治疗,观察组给予硫酸镁联合丹参注射液治疗,对比两组的治疗效果。结果治疗后,观察组的NT-pro BNP、IL-6、TNF-a、hs-CRP水平均显著低于对照组(P<0.05)。观察组的自然分娩率显著高于对照组,产后出血率、低体重儿率、胎盘早剥率、胎儿窘迫率、新生儿窒息率均显著低于对照组(P<0.05)。结论硫酸镁联合丹参注射液治疗早发型子痫前期患者可显著降低NT-pro BNP和炎性细胞因子水平,改善妊娠结局。

Objective To explore the effects of treatment of magnesium sulfate combined with Danshen injection on the levels of NT-pro BNP and inflammatory cytokines in patients with early-onset preeclampsia. Methods 100 cases of patients with early-onset preeclampsia were selected and randomly divided into two groups, with 50 cases in each group. The control group was treated with magnesium sulfate, while the observation group was treated with magnesium sulfate combined with Danshen injection. The curative effects of two groups were compared. Results After treatment, the levels of NT-pro BNP, IL-6, TNF-a and hs-CRP of the observation group were significantly lower than those of the control group（P〈0.05）. The spontaneous delivery rate of the observation group was significantly higher than that of the control group, and the postpartum hemorrhage rate, rate of low birth weight infants, placental abruption rate, fetal distress rate and neonatal asphyxia rate were significantly lower than those of the control group（P〈0.05）. Conclusions Magnesium sulfate combined with Danshen injection for the treatment of patients with early-onset preeclampsia can significantly lower the levels of NT-pro BNP and inflammatory cytokines, and improve the pregnancy outcome.