氯吡格雷联合阿司匹林对非心源性缺血性卒中患者的预防效果及安全性

Prevention Efficacy and Safety of Clopidogrel Combined with Aspirin in Patients with Non-Cardiac Ischemic Stroke

目的探讨氯吡格雷联合阿司匹林对非心源性缺血性卒中的二级预防效果及安全性。方法 82例非心源性缺血性卒中患者随机均分为对照组(予以阿司匹林口服)与观察组(予以阿司匹林联合氯吡格雷口服),观察缺血性卒中的复发率及用药期间的不良反应情况。结果观察组6个月内的复发率为14.6%,显著低于对照组的31.7%(P<0.05);观察组的不良反应发生率为7.3%,显著低于对照组的36.6%(P<0.05)。结论氯吡格雷联合阿司匹林对于缺血性卒中的预防效果确切,安全性尚可。

Objective To explore the secondary prevention effect and safety of clopidogrel combined with aspirin in patients with non-cardiac ischemic stroke. Methods 80 cases of patients with non-cardiac ischemic stroke were randomly divided into the control group（oral administration of aspirin） and the observation group（oral administration of clopidogrel combined with aspirin） equally. The recurrence rate of ischemic stroke and adverse reactions during medication were observed. Results The recurrence rate within 6 months of the observation group was 14.6%, significantly lower than 31.7% of the control group（P〈0.05）. The incidence of adverse reactions of the observation group was 7.3%, significantly lower than 36.6% of the control group（P〈0.05）. Conclusions Clopidogrel combined with aspirin has exact prevention effect of ischemic stroke and acceptable safety.