感染性肺部疾病中肿瘤标记物SCC、NSE表达水平的临床分析

Clinical Analysis on the Expression Levels of Tumor Markers SCC and NSE in Pulmonary Infection Diseases

目的探讨肿瘤标记物SCC、NSE在感染性肺部疾病临床诊断中的价值。方法选择我院2015年4月至2017年4月收治的40例肺癌患者作为观察组,同期40例肺部感染性良性疾病住院患者作为对照组,检测并比较两组患者的血清SCC和NSE水平。结果 SCC在非小细胞肺癌患者、小细胞肺癌患者和对照组患者的阳性率分别为86.67%、33.33%、0.00%,NSE在非小细胞肺癌、小细胞肺癌和对照组患者中的阳性率分别0.00%、50.00%、0.00%。观察组和对照组的SCC水平分别为(6.06±10.20)ng/m L、(1.12±1.04)ng/m L,NSE水平分别为(3.43±2.78)ng/m L、(1.80±1.51)ng/m L,组间差异有统计学意义(均P<0.01)。结论肿瘤标记物SCC、NSE在肺部肿瘤患者的诊断、鉴别诊断和治疗中有较高的应用价值。

Objective To investigate the value of tumor markers SCC and NSE in the clinical diagnosis of pulmonary infection diseases. Methods 40 cases of patients with lung cancer admitted to our hospital from April 2015 to April 2017 were selected as the observation group, and another 40 cases of inpatients with benign pulmonary infection diseases at the same period were selected as the control group. The levels of serum SCC and NSE of two groups were detected and compared. Results The positive rates of SCC in patients with non-small cell lung cancer, patients with small cell lung cancer, and patients in the control group were 86.67%, 33.33% and 0.00%respectively, and the positive rates of NSE were 0.00%, 50.00% and 0.00% respectively. The levels of SCC and NSE of the observation group were（6.06 ± 10.20） ng/m L and（3.43 ± 2.78） ng/m L respectively, significantly higher than（1.12 ± 1.04） ng/m L and（1.80 ± 1.51）ng/m L of the control group, with statistical differences（both P〈0.01）. Conclusions Tumor markers SCC and NSE are of high value in the diagnosis, differential diagnosis and treatment of pulmonary infectious diseases.