钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病的疗效观察

Observation on the Curative Effect of Sequential Therapy with Calcipotriol Betamethasone Cream and Calcipotriol Ointment for Psoriasis

目的探讨钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病的临床效果。方法 80例银屑病患者随机分为两组各40例,对照组采用外用卡泊三醇软膏治疗,观察组采用钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗,比较两组患者的临床治疗效果。结果观察组的总有效率为90.0%,显著高于对照组的70.0%(P<0.05)。治疗后,观察组的银屑病皮损程度评分显著优于对照组(P<0.05)。观察组的不良反应发生率为2.5%,显著低于对照组的17.5%(P<0.05)。结论采用钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病的效果显著,可改善患者的皮损程度,安全性高,值得临床推广应用。

Objective To explore the clinical effect of sequential therapy with calcipotriol betamethasone cream and calcipotriol ointment for psoriasis. Methods 80 cases of patients with psoriasis were randomly divided into two groups, with 40 cases in each group. The control group was treated with calcipotriol ointment for external application, and the observation group was given sequential therapy with calcipotriol betamethasone cream and calcipotriol ointment. The clinical curative effects of the two groups were compared. Results The total effective rate of the observation group was 90.0%, significantly higher than 70.0% of the control group（P〈0.05）. After treatment, the score of psoriasis skin lesion of the observation group was significantly better than that of the control group（P〈0.05）. The incidence of adverse reactions of the observation group was 2.5%, significantly lower than 17.5% of the control group（P〈0.05）. Conclusions The sequential therapy with calcipotriol betamethasone cream and calcipotriol ointment for psoriasis has significant efficacy and high safety,which can improve patients＇ skin lesion degree, and is worthy of clinical promotion and application.