NK细胞毒受体抗肝细胞癌的研究进展

Research Advance of NK Cytotoxicity Receptors Treat on Hepatocellular Carcinoma

目的：肝细胞癌（HCC）已经成为全球最常见的恶性肿瘤之一，成为我国第二大癌症死因。随着对免疫学研究的深入及免疫治疗的开展，发现免疫细胞具有显著的抗癌作用，但其具体机制及作用靶点尚不清楚。HCC患者免疫力低下，NCRs数量减少，NK活性降低是HCC发展、转移的一个重要因素，NCRs是NK细胞发挥免疫杀伤的重要机制，增强NCRs活性是NK细胞发挥抗肿瘤作用的重要方法，笔者主要综述了目前关于固有免疫细胞NK通过NCRs发挥抗肿瘤作用机制的研究进展，探讨通过激活或增强NCRs增强NK细胞活性，改善HCC患者NK细胞活性低下，提高其抗HCC的作用。

Objective：Hepatocellular carcinoma has been the common cancer in the world and the second cancer death in China. Along with immunology and immune treatment developing, which has finding immune cells have anti -tumor effect, but unclear the mechanism and targets. HCC patients have lower immune and NCRs amounts, which is vital factors of HCC develops and metastasis. NCRs are important mechanism of NK immune killer effects, enhance activity of NCRs can improve the immune killer of NK to tumor. This article reviews the progress and mechanism of NK anti - tumor through NCRs, and discusses how to active and enhance NK activity to improve anti - tumor effect.