AMPK信号通路在肝癌中的研究进展

Advances of AMPK Signaling Pathway in Hepatocellular Carcinoma

原发性肝癌发病率在全世界常见恶性肿瘤中位居第5位,死亡率位居第3位,其中90%以上的原发性肝癌属肝细胞肝癌。AMPK信号通路是一种高度保守的丝氨酸/苏氨酸蛋白通路,是广泛存在于哺乳动物体内的一种能量调节器,通过促进分解代谢、抑制合成代谢来调控肿瘤细胞的生长代谢。有研究证实当AMPK在肝脏中频繁发生异常表达及激活突变,其通过多种机制促进肝癌的发生发展,而且与肝癌的治疗及预后密切相关。因此,AMPK信号通路可作为一个新的靶标,为肝癌的诊断和治疗提供新的策略与思路。

The incidence of primary liver cancer is the fifth most common malignancy over the world with the third highest mortality rate.More than 90% of primary liver cancer is hepatocellular carcinoma.AMPK signal pathway is a highly conserved serine/threonine protein pathway.It is an energy regulator that widely exists in mammals and regulates the growth and metabolism of tumor cells by promoting catabolism and inhibiting anabolism.Studies have shown that when AMPK is frequently expressed abnormally in the liver and activation of mutations,which through a variety of mechanisms to promote the occurrence and development of hepatocellular carcinoma,but also with the treatment and prognosis of hepatocellular carcinoma are closely related.Thus,AMPK signaling may become a potential target for treatment,providing new directions and strategies for HCC.