临床药师干预碳青霉烯类抗菌药物临床应用的效果分析

Analysis of Intervention Effects by Clinical Pharmacist on the Use of Antibacterial Agents of Carbon Penicillium

目的探讨临床药师对碳青霉烯类抗菌药物使用实施干预的效果。方法回顾性分析比较我院2016年4月~9月(干预前)与2017年4月~9月(干预后)碳青霉烯类抗菌药物临床使用情况。结果经干预后,碳青霉烯类抗菌药物使用率、使用强度、使用量占抗菌药物百分率分别为由1.44%、1.63 DDD和3.69%,下降为1.12%、0.90 DDD和2.96%。用药指征合理率、用法用量合理率、用药使用前微生物送检率、相关科室会诊比率分别由76.30%、83.19%、83.72%、18.5%提高到90.50%、94.03%、91.35%、56.1%。对我院常见的肺炎克雷伯菌、鲍曼不动杆菌及铜绿假单胞菌的耐药率均呈不同程度下降。结论临床药师干预碳青霉烯类抗菌药物使用是有效的、可行的,在促进碳青霉烯类抗菌药物临床合理使用的同时遏制了细菌耐药的进展。

Objective To explore the intervention effects by clinical pharmacist on the use of antibacterial agents of carbon penicillium. Methods Retrospective analysis compared the clinical use of antibacterial agents of carbon penicillium from April to September 2016（before intervention） and from April to September 2017（after intervention）. Results After intervention by clinical pharmacist, the rate of use, intensity, and percentage of antibacterials use decreased from 1.44%,1.63 DDD, 3.69% to 1.12%, 0.90 DDD, 2.96% respectively. The reasonable ratio of medication indications, the reasonable ratio of usage, microbial delivery rate and consultation ratio increased from6.30%, 83.19%, 83.72%, 18.5% to 90.50%, 94.03%, 91.35%, 56.1% respectively. The drug resistance rate of klebsiella pneumoniae, pseudomonas aeruginosa and pseudomonas aeruginosa were decreased in different degrees. Conclusions Clinical pharmacist＇s intervention is effective and feasible to he use of antibacterial agents of carbon penicillium, in promoting the clinical use of antibacterial agents of carbon penicillium, the progress of bacterial resistance was also suppressed.