期刊文献+

奥沙利铂联合表柔比星、氟尿嘧啶治疗中晚期原发性肝癌69例疗效分析 被引量:5

下载PDF
导出
摘要 目的对奥沙利铂联合表柔比星、氟尿嘧啶治疗中晚期原发性肝癌的疗效进行分析探讨,为中晚期原发性肝癌临床治疗方法的选择提供参考依据。方法选取2015年6月至2016年9月我院收治的中晚期原发性肝癌患者138例,随机分为治疗组和对照组,每组患者69例,治疗组给予奥沙利铂联合表柔比星、氟尿嘧啶行TACE治疗;对照组给予卡铂联合表柔比星、氟尿嘧啶行TACE治疗。治疗后比较两组患者治疗有效率、总生存期及不良反应情况。结果治疗组治疗总有效率为69.57%,对照组为66.67%,差异无显著性(P>0.05),说明两种治疗方案治疗中晚期原发性肝癌的临床疗效无显著性差异;治疗组和对照组患者治疗后半年内的生存率无显著差异(P>0.05),1年内生存率治疗组(40.58%)明显高于对照组(28.99%)(P<0.05);对照组不良反应发生情况比治疗组严重。结论 TACE术中植入奥沙利铂联合表柔比星、氟尿嘧啶治疗中晚期原发性肝癌,远期疗效较好,不良反应相对较小。
机构地区 吉林省肿瘤医院
出处 《中国医药指南》 2018年第15期89-90,共2页 Guide of China Medicine
  • 相关文献

参考文献4

二级参考文献34

  • 1Yang-Kui Gu, Rong-Guang Luo, Jin-Hua Huang, Qi-Jiao Si Tu, Xiao-Xia Li, Fei Gao,State Key Laboratory of Oncology in Southern China,Department of Medical Imaging and Interventional Radiology,Cancer Center,Sun Yat-sen University,Guangzhou510060,Guangdong Province,China,Department of Medical Imaging and Interventional Radiology, the First Affiliated Hospital of Nan-Chang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China.Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture[J].World Journal of Gastroenterology,2010,16(45):5766-5772. 被引量:10
  • 2秦叔逵,曹梦苒,钱军,华海清,王琳,何泽明.奥沙利铂为主的FOLFOX方案治疗晚期原发性肝癌[J].临床肿瘤学杂志,2005,10(1):58-60. 被引量:77
  • 3Mizukoshi E, Nakamoto Y, Arai K, et al. Comparative analysis of various tumor associated antigen specific t cell responses in patients with hepatocellular carcinoma[J]. Hepatology, 2011, 53: 1206 1216.
  • 4Fu JL, Xu DP, Liu ZW, et al. Increased regulatory T cells correlate with CD8 T cell impairment and poor survival in hepatocellular carcinoma patients[J]. Gastroenterology, 2007, 132: 2328 2339.
  • 5O’Beirne JP, Harrison PM. The role of the immune system in the control of hepatocellular carcinoma[J]. Eur J Gastroenterol Hepatol. 2004, 16: 1257 1260.
  • 6Cho Y, Miyamoto M, Kato K, et al. CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma[J]. Cancer Res, 2003, 63: 1555 1559.
  • 7Chen X, Du Y, Huang ZM. CD4+ CD25+ Treg derived from hepatocellular carcinoma mice inhibits tumor immunity[J]. Immunol Lett, 2012, 148: 83 89.
  • 8Almeida AR, Ciernik IF, Sallusto F, et al. CD4+ CD25+ Treg regulate the contribution of CD8+ T cell subsets in repopulation of the lymphopenic environment[J]. Eur J Immunol, 2010, 40: 3478 3488.
  • 9Mcnally A, Hill GR, Sparwasser T, et al. CD4+ CD25+ regulatory T cells control CD8+ T cell effector differentiation by modulating IL 2 homeostasis[J]. Proc Natl Acad Sci USA, 2011, 108: 7529 7534.
  • 10Zhao F, Korangy F, Greten TF. Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma[J]. Dig Dis, 2012, 30: 477 482.

共引文献71

同被引文献54

引证文献5

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部