噻托溴铵粉吸入剂思力华联合盐酸氨溴索治疗老年COPD急性加重期的疗效及预后

Tiotropium Bromide Powder for Inhalation Tiotropium Combined with Ambroxol Hydrochloride in the Treatment of Curative Effect and Prognosis of Acute Exacerbation of Elderly COPD

目的探讨噻托溴铵粉吸入剂思力华联合盐酸氨溴索治疗老年COPD急性加重期的疗效及预后。方法选取我院(2013年1月至2017年12月)收治的80例老年COPD急性加重期患者为研究对象,根据治疗方法不同分为两组,对照组40例患者给予常规治疗,观察组40例患者给予噻托溴铵粉联合盐酸氨溴索治疗,对比两组治疗前二氧化碳分压(PaCO_2)、血氧分压(PaO_2)、1 s呼气容积(FEV1)、呼气峰流速(PEF)指标及治疗后生活质量。结果治疗前两组患者Pa CO_2、PaO_2、FEV_1、PEF指标对比无显著差异,不具有统计学意义(P<0.05)。治疗后观察组患者PaCO_2指标明显低于对照组,PaO_2、FEV_1、PEF指标明显高于对照组,差异具有统计学意义(P<0.05)。观察组患者社会功能、心理状态、躯体功能、生理功能明显高于对照组,差异具有统计学意义(P<0.05)。结论噻托溴铵粉联合盐酸氨溴索治疗老年COPD急性加重期效果显著,可有效稳定患者血氧指标和肺功能,改善患者生活质量,值得临床推广。

Objective To investigate the Tiotropium Bromide Powder for Inhalation Spiriva combined with ambroxol hydrochloride in curative effect and prognosis of the treatment for acute exacerbation of elderly COPD. Methods In our hospital from January 2013 to December 2017 80 cases of elderly patients with acute exacerbation of COPD as the research object, according to the different treatment methods were divided into two groups, 40 patients in the control group were given routine treatment, 40 patients in observation group were given tiotropium bromide powder combined with ambroxol hydrochloride treatment, compared between the two groups before treatment, the partial pressure of carbon dioxide（PaCO_2）, blood pressure（PaO_2）, LS expiratory volume（FEV1）, peak expiratory flow rate（PEF） index and quality of life after treatment. Results Before treatment, there was no significant difference between the two groups of PaCO_2, PaO_2, FEV_1 and PEF, and there was no statistical significance（P〈0.05）. After treatment, the PaCO_2 index in the observation group was significantly lower than that of the control group, and the indexes of Pa O2, FEV1 and PEF were significantly higher than those in the control group, and the difference was statistically significant（P〈0.05）. The social function, mental state, physical function and physiological function of the observation group were significantly higher than those of the control group, and the difference was statistically significant（P〈0.05）. Conclusion Tiotropium bromide combined with ambroxol hydrochloride is effective in the treatment of acute exacerbation of COPD in elderly patients. It can effectively stabilize blood oxygen index and pulmonary function and improve the quality of life of patients, which is worthy of clinical promotion.