自身抗体检测对自身免疫性肝病诊断的临床意义

The Clinical Significance of Autoantibody Detection in the Diagnosis of Autoimmune Liver Disease

目的探讨自身免疫性肝病诊断采用自身抗体检测的临床意义。方法采用免疫印迹法和酶联免疫吸附法检测慢性病毒性肝炎患者和自身免疫性肝病患者中血清的LCI抗体、ANA、gp-210、AMA-M2、SP100、SLA/LP、LKM-1。结果 AIH的SLA/LP和LKM-1的阳性检出率明显高于HBV和HCV,差异显著,有统计学意义,P<0.05;PBC的AMA-M2和gp-210的阳性检出率明显高于HBV和HCV,差异显著,有统计学意义,P<0.05。结论自身抗体检测对自身免疫性肝病诊断和鉴别有重要临床意义。

Objective To study the autoantibodies to detect the clinical significance of autoimmune liver disease diagnosis. Methods Using western blot method and enzyme-linked immunosorbent method detection and autoimmune liver disease in patients with chronic viral hepatitis patients serum antibody of LCI, ANA, gp-210, the AMA-M2, SP100, SLA/LP, LKM-1. Results AIH SLA/LP and positive detection rate of LKM-1 was obviouslyhigher than that of HBV and HCV, significant difference was statistically significant, P0.05; PBC AMA-positive detection rate of M2 and gp-210 was obviouslyhigher than that of HBV and HCV, significant difference was statistically significant, P0.05）. Conclusion Autoantibodies detection of autoimmune liver disease diagnosis and identification has important clinical significance.