多巴胺联合硝普钠持续静脉泵入治疗老年顽固性心力衰竭的效果及对心功能的影响

Effect of Dopamine combined with Nitroprusside Continuous Intravenous Infusion on Intractable Heart Failure in Elderly Patients and Its Influence on Cardiac Function

目的探讨多巴胺联合硝普钠持续静脉泵入治疗老年顽固性心力衰竭的效果及对心功能的影响。方法研究将选取2015年9月至2018年1月的间在我院进行老年顽固性心力衰竭治疗的患者176例作为探究主体,按照患者入院时间的奇偶性将患者的分为实验组与对照组,对照组患者单独使用多巴胺进行治疗,实验组患者采用多巴胺与硝普钠联合用药的方法进行治疗,观察两组患者的治疗效果以及治疗后心功能各项指标。结果实验组患者的治疗有效率为98.86%,对照组患者的治疗有效率为89.77%,两组患者的治疗有效率比较,差异具有统计学意义(P<0.05),实验组患者的射血分数为(54.25±2.15)%、每搏指数(36.52±3.64)、左室舒张末期内径(55.94±6.12)mm、左室收缩末期内径(37.16±3.69)mm,对照组患者的射血分数为(48.25±3.14)%、每搏指数(29.37±2.54)、左室舒张末期内径(47.92±5.42)mm、左室收缩末期内径(43.94±4.56)mm,两组患者的心功能各项指标比较,差异具有统计学意义(P<0.05)。结论多巴胺联合硝普钠持续静脉泵入治疗老年顽固性心力衰竭效果确切,能够使患者的心功能得到较明显的改善,并具有较高的安全性,该治疗方法应在临床中广泛应用。

Objective To explore the effect of continuous intravenous infusion of dopamine combined with nitroprusside in the treatment of elderly patients with intractable heart failure and its influence on cardiac function. Methods 176 cases of elderly intractable heart failure treated in our hospital from September 2015 to January 2018 were selected as the subject of inquiry. The patients were divided into the experimental group and the control group according to the parity of the patients＇ admission time. The patients in the control group were treated with dopamine alone, and the patients in the experimental group were used more. The combination therapy of sodium and sodium nitroprusside was used to treat the two groups of patients, and the indexes of cardiac function after treatment were observed. Results The effective rate of the patients in the experimental group was 98.86%, the effective rate of the control group was 89.77%. The effective rate of the two groups was statistically significant（P〈0.05）. The ejection fraction of the patients in the experimental group was（54.25±2.15）%, the stroke index（36.52±3.64） and the left ventricular end diastolic diameter（55.94±6.12） mm and left ventricular end systolic diameter（37.16±3.69） mm, the ejection fraction of the control group was（48.25±3.14）%, the stroke index（29.37±2.54）, the left ventricular end diastolic diameter（47.92±5.42） mm, and the left ventricular end systolic diameter（43.94±4.56）. The differences of the cardiac function indexes of the patients in the two groups were different. The significance of the study（P〈0.05）. Conclusion The effect of dopamine combined with sodium nitroprusside intravenous infusion in the treatment of senile intractable heart failure is accurate. It can improve the cardiac function of the patients and have high safety. This method should be widely used in clinical practice.