液体活检在膀胱癌中的研究进展

Research advances of liquid biopsy in the detection of bladder cancer

本文探讨现行的各种类型的液体活检在临床上的应用,特别是与膀胱癌分子标记物相关的检测。液体活检目前因其可以实时检测肿瘤患者疾病状态而被关注,液体活检无创、易重复,可检测与膀胱癌靶向治疗或者治疗抵抗相关基因的改变,并且液体活检对无法组织活检的患者可以达到接近标记物评估水平的手段。液体活检在膀胱中将会广泛应用于监测、推测预后、选择靶向治疗等方向。

In this review,we will discuss the types of liquid biopsies currently available,especially as they relate to the detection of molecular biomarkers of bladder cancer.Liquid biopsy has recently received enormous attention as a potential tool for real-time monitoring of disease status in cancer patients,and genomic profiles are reported to closely match those of corresponding tumors.It is noninvasive and easily repeated,and allows monitoring during treatment and detection of different genomic alterations that are potentially accessible to targeted therapy or are associated with treatment resistance in bladder cancer patients.Moreover,liquid biopsy is a tool that allows rapid access to biomarker assessment in patients for whom solid biopsies are not available.Liquid biopsy will be widely applied to daily clinical practice and serve as an important tool for the screening,surveillance,prediction of outcomes,and selection of effective targeted therapies in bladder carcinoma.