乌司他丁联用奥曲肽治疗术后炎性肠梗阻的疗效及对血清炎性因子的影响分析

Effect of ulinastatin combined with octreotide on postoperative inflammatory ileus and its influence on serum inflammatory factors

目的探讨联合应用乌司他丁与奥曲肽治疗腹部手术术后炎性肠梗阻的临床效果及对血清炎性因子影响。方法选择腹部手术术后炎性肠梗阻患者92例,均为我院2016年2月~2018年2月收治,采用数字表抽取法随机分组,对单用奥曲肽治疗(对照组,n=46)与联用乌司他丁治疗(观察组,n=46)效果及血清炎性因子展开对比。结果观察组总有效率为95.7%,对照组为78.3%,差异有统计学意义(P<0.05);观察组血清炎性因子IL-8、hs-CRP、TNF-α水平治疗后明显低于对照组,差异有统计学意义(P<0.05);观察组腹部症状消失时间、住院时间明显少于对照组,差异有统计学意义(P<0.05)。结论针对临床收治的腹部手术术后炎性肠梗阻患者,应用乌司他丁与奥曲肽联用方案治疗,可显著提高临床效果,降低炎症反应,加快康复进程,具非常积极的应用价值。

Objective To explore the clinical effect of ulinastatin combined with octreotide on postoperative inflammatory ileus and its influence on serum inflammatory factors. Methods Ninety-two patients with inflammatory bowel obstruction after abdominal surgery who treated in Yuancheng District Second People＇s Hospitals from February 2016 to February 2018 were selected, and randomly divided into two groups by digital table extraction. The patients were treated with octreotide alone（control group, n=46） and combined use ofulinastatin（observation group, n=46）. The effect of treatment and serum inflammatory factors were compared. Results The total effective rate of the observation group was 95.7%, while that of the control group was 78.3%, the difference was statistically significant（P 〈0.05）. The levels of serum inflammatory factors IL-8, hs-CRP and TNF-alpha in the observation group were significantly lower than those in the control group after treatment（P 〈0.05）. The time of abdominal symptom disappearance and hospitalization time in the observation group were significantly less than those in the control group, the difference was statistically significant（P 〈0.05）. Conclusion The combination of ulinastatin and octreotide for patients with postoperative inflammatory bowel obstruction after abdominal surgery can improve the clinical effect, reduce the inflammatory reaction and accelerate the process of rehabilitation. It has a very positive application value.