广州市乙型肝炎疫苗免疫策略

Immunization strategy of hepatitis B vaccine in Guangzhou City

目的分析广州市乙型肝炎(乙肝)疫苗免疫策略的效果,为乙肝防控提供参考。方法检索1992~2016年乙肝免疫策略文献、收集乙肝血清学数据、乙肝疫苗查漏补种及入学验证接种率数据进行分析。结果广州市1~59岁人群HBsAg流行率为12.45%,且<5岁儿童HBsAg流行率为0.48%;2001年、2008年和2009~2011年实施3次乙肝疫苗查漏补种,接种率分别为92.44%、97.14%和99.08%;采取入学验证制度,2007~2009年乙肝疫苗补种率为49.83%,2010~2016年上升到96%以上。结论广州市实施乙肝疫苗免疫策略后,乙肝表面抗原(HBsAg)流行率在免疫人群中显著下降,<5岁儿童HBsAg流行率已控制在<1%,控制乙肝取得显著成果。

Objective To analyze the effect of hepatitis B vaccine immunization strategy in Guangzhou City and provide reference for prevention and control of hepatitis B. Methods The literature on immunization strategy of hepatitis B from1992 to 2016 was retrieved and the serological data of hepatitis B was selected, the vaccination coverage and re-vaccination of hepatitis B vaccine and the vaccination rate at primary school enrolment were analyzed. Results The prevalence rate of HBsAg in 1~59 year old population in Guangzhou was 12.45%, and the prevalence rate of HBsAg for children less than 5 years old was 0.48%. In 2001, 2008 and 2009-2011 years, the vaccination coverage and re-vaccination of hepatitis B vaccine were implemented of the 3 missing immunization, the vaccination rates were 92.44%, 97.14% and 99.08%. Take the entrance verification system, the rate of replanting of hepatitis B vaccine in 2007-2009 years was 49.83%, 2010-2016 years rose to more than 96%. Conclusion The implementation of Hepatitis B vaccine immunization strategy in Guangzhou City, Hepatitis B virus surface antigen（HbsAg） prevalence rate was significantly decreased in the immune population, the prevalence rate of HBsAg in children less than 5 years old has been controlled at 〈 1%, and significant results have been achieved in controlling hepatitis B.