腹腔开放创面的早期保护

Early protection of exposed intra-abdominal organs in open abdomen therapy

腹腔开放疗法是治疗腹部战创伤与腹腔感染的突破性进展,是治疗腹部战创伤与严重腹腔感染有效的治疗措施。但肠破裂、肠空气瘘是腹腔开放疗法的严重并发症,是阻碍腹腔开放疗法的主要难题。研究腹腔开放创面发生发展的病理生理,开展腹腔开放创面保护的理论与基础研究是解决这一难题的关键。基于研制出的自体纤维蛋白胶、静电纺丝钠米纤维膜、生物响应性水凝胶等生物医学材料,通过发挥止血、消炎抗菌、促增殖等作用,达到对腹腔开放创面的早期保护的目的。

Open abdomen therapy（OA） is a breakthrough in treating abdominal trauma and infections. Enterorrhexis and entero-atmospheric fistula are both severe complications of OA and impact the therapeutic effect of OA seriously. To solve this problem,the pathophysiology of the OA wound formation and development,and the early protection measures of the OA wound are studied. Many biomaterials were developed,including autologous fibrin glue,electrospinning nanofiber membrane and hydrogel,to realize the target of early protection of the OA wound through hemostasis,anti-infection,antioxidation,and proliferation promoting.