癌性疼痛相关离子通道的研究进展

Advances in studies on cancerous pain-related ion channels

随着肿瘤诊断、治疗水平的提高,肿瘤患者的生存时间逐渐延长,但往往出现疼痛等并发症。由于对癌性疼痛机制认识不清,临床镇痛治疗效果不佳,严重影响肿瘤患者的生存质量。离子通道为跨膜糖蛋白,激活后能产生并传导电信号,参与机体多种生理及病理功能调节。离子通道功能改变在癌性疼痛的形成和维持机制中扮演了重要的角色。文章将近年来癌性疼痛机制中几种主要离子通道的研究进展做一总结,为下一步癌性疼痛的离子通道机制研究及相关药物的开发提供参考。

With the improvement of tumor diagnosis and treatment,the survival time in cancer patients has been gradually prolonged,but the complications such as severe pain are often found. Due to the unrevealed mechanisms of cancer pain,clinical analgesic treatments are unsatisfied needs,and the cancerous pain seriously affected the life quality of icancer patients. Ion channels are the transmembrane glycoproteins which produce and transmit electrical signals when activated,and involved in the regulation of a variety of physiological and pathological processes. Alterations in the ion channel function may play an important role in the formation and maintenance of cancer pain. In this review,the research developments of several major ion channels in the mechanisms of cancer pain in recent years are summarized,which can provide some useful references for the study of ion channel and related drug development of cancer pain.