肥胖诱导骨质疏松的分子机制研究进展

Research progress on the mechanisms of obesity induced osteoporosis

传统观念认为,超重或肥胖对骨质量具有保护作用。近年越来越多的研究证实,肥胖与骨质疏松的发生有关。肥胖可涉及骨凋亡、骨形成、骨分化、骨微循环、骨吸收等的多条信号通路表达发生改变。肥胖可改变不同类型的骨生长因子、促炎症细胞因子、激素的受体等因子的表达,诱导促使成骨细胞分化、成熟、存活的各类型转录因子激活,同时肥胖还可激活调节破骨细胞作用的信号通路。文章主要就肥胖对成骨作用、破骨作用的影响以及其分子生物学机制以及对肥胖诱导骨质疏松发生的分子机制的研究进行综述。

Traditionally,overweight or obesity has a protective effect on bone quality. In recent years,more and more studies have confirmed that obesity is associated with osteoporosis. Obesity can be involve in many signaling pathways such as bone marrow apoptosis,bone formation,bone differentiation,bone microcirculation,bone resorption,and so on. Obesity can change the expression of different types of factors such as bone growth factor,proinflammatory cytokine and hormone receptor,inducing the activation of various types of transcription factors that induce osteoblast differentiation,maturation and survival,and obesity also activates the signaling pathway regulating the role of osteoclasts. This article reviews the effects and molecular mechanisms of obesity on osteogenesis,osteoclast as well as the molecular mechanisms of obesity induced osteoporosis.