口服氨甲环酸片及复方甘草酸苷片治疗黄褐斑临床疗效分析

Analysis on the clinical efficacy of oral tranexamic acid tablets and compound glycyrrhizin tablets in the treatment of chloasma

目的分析口服氨甲环酸片及复方甘草酸苷片治疗黄褐斑的临床疗效和不良反应。方法选取泉州市皮肤病防治院激光美容门诊54例黄褐斑患者,随机分为2组,每组27例。A组:口服氨甲环酸片0.5mg qd,维生素C 0.3 tid,疗程为5个月。B组在A组治疗基础上,头三个月加口服复方甘草酸苷片1片(75mg)tid,全部给予健康宣教和保湿防晒。在疗程结束时,计算总有效率、患者满意度、观察到的副作用。疗程结束后2个月观察复发情况。结果总疗程结束后,A组总有效率为66.67%,B组总有效率的88.89%。A组低于B组。患者满意度为A组40.74%,B组77.78%。两组差异具有统计学意义(P<0.05)。疗程结束后2个月复查B组无明显复发。A组有1例觉得颜色加深,但也比治疗前浅。结论口服氨甲环酸片及复方甘草酸苷片治疗黄褐斑疗效确切、方便安全、患者满意度高,值得临床推广。

Objective To analyze the clinical efficacy and adverse reactions of oral tranexamic acid tablets and compoundglycyrrhizin tablets in the treatment of chloasma. Methods 54 patients with chloasma were randomly divided into 2 groups and 27patients in each group. Group A： oral tranexamic acid tablets 0.5mg qd, vitamin C 0.3 tid, A course of 5 months. In group B, on thebasis of treatment in group A, one tablet （75mg） tid of compound glycyrrhizin tablets was added orally in the first three months, andall of them were given health education and moisturizing sunscreen. At the end of the course, total efficiency, patient satisfaction, andobserved side effects are calculated. Recurrence was observed 2 months after the end of treatment.. Results The total effective ratewas 66.67% in group A and 88.89% in group B. Group A is lower than group B. The patients＇ satisfaction was 40.74% in group A and77.78% in group B. The difference between the two groups was statistically significant （P 〈0.05）. No significant recurrence was foundin group B after reexamination 2 months after the end of treatment. One patient in group A felt darker but lighter than before treatment.Conclusion Oral administration of aminocyclic acid tablets and compound glycyrrhizin tablets is effective, convenient and safe in thetreatment of chloasma.