血脂比值与视网膜血管管径的相关性

Relationship between Lipoprotein Ratios and Retinal Vessel Diameter

目的探讨血脂比值与视网膜血管管径间的相关关系.方法：横断面研究.收集2010 年1-12 月在广州市第十一人民医院体检的无严重心脑血管疾病史且年龄在40岁及以上的广州市公务员4 882名,对该群体进行血脂蛋白浓度的监测,并采集研究对象同时期的眼底彩照.采用科学有效的眼底血管分析软件（IVAN软件）测定视网膜动静脉管径.采用多重线性回归模型分析低密度脂蛋白/高密度脂蛋白（LDL/HDL）、载脂蛋白B/高密度脂蛋白（ApoB/HDL）、载脂蛋白B/载脂蛋白A1（ApoB/ApoA1）、总胆固醇/高密度脂蛋白（TC/HDL）、甘油三酯/高密度脂蛋白（TG/HDL）和低密度脂蛋白/载脂蛋白B（LDL/ApoB）等6 种血脂比值与视网膜血管管径的相关关系.结果：最终纳入研究对象4 715 名.在矫正年龄、性别等传统心脑血管危险因素后,多重线性回归分析发现LDL/HDL、ApoB/HDL、ApoB/ApoA1比值与视网膜动脉管径呈负相关性（β=-0.61,P=0.046;β=-1.91,P=0.020;β=-2.58,P=0.010）,与视网膜静脉管径呈正相关性（β=2.01、4.63、5.99,均P 〈 0.001）.而TC/HDL、TG/HDL、LDL/ApoB比值与视网膜动静脉管径均无相关性.结论：LDL/HDL、ApoB/HDL、ApoB/ApoA1比值为视网膜血管管径的危险因素,TC/HDL、TG/HDL、LDL/ApoB比值对视网膜血管管径无明显影响.

Objective： To investigate the relationship between six lipoprotein ratios and retinal vascular diameter.Methods： This cross-sectional study was performed from January 2010 to December 2010 and included4 882 Chinese government officials age ≥40 years in Guangzhou who had no history of major cardiovascularevents such as stroke or myocardial infarction. Serum lipids were analyzed and retinal vascular caliber wasassessed using standard fundus photographs and validated software. A multiple linear regression model wasdesigned to analyze the relationship between the following conditions： low density lipoprotein cholesterol/highdensity lipoprotein cholesterol （LDL/HDL）, apolipoprotein B/high density lipoprotein cholesterol（ApoB/HDL）, apolipoprotein B/apolipoprotein A1 （ApoB/ApoA1）, total cholesterol/high density lipoproteincholesterol （TC/HDL）, triglyceride/high density lipoprotein cholesterol （TG/HDL）, low density lipoprotein cholesterol/apolipoprotein B （LDL/ApoB） ratios and retinal vascular diameter. Results： After adjustmentfor traditional cardiovascular risk factors, multiple linear regression analysis showed that LDL/HDL, ApoB/HDL, and ApoB/ApoA1 ratios all have a negative correlation with retinal arterial caliber （ β=-0.61, -1.91,-2.58, P=0.046, 0.020, 0.010 respectively）. However, they have a positive correlation with retinal venouscaliber （ β=2.01, 4.63, 5.99, respectively, P 〈 0.001）. The relationships between TC/HDL, TG/HDL, andLDL/ApoB and retinal vascular caliber were not statistically significant. Conclusions： LDL/HDL, ApoB/HDL, and ApoB/ApoA1 ratios are significantly associated with a decrease in the retinal vascular caliber.The ratios of TC/HDL, TG/HDL, and LDL/ApoB are not associated with retinal vascular caliber.