低分子量肝素治疗不稳定型心绞痛临床观察

Clinical observation of low molecular weight heparin in the treatment of unstable angina pectoris

目的 :观察腹壁皮下注射低分子量肝素治疗不稳定型心绞痛的疗效和不良反应。方法 :选择不稳定型心绞痛患者98例 ,随机分为低分子量肝素组和对照组进行疗效比较。对照组常规服用硝酸盐类、β 受体阻滞剂、钙通道拮抗剂 ,5 %葡萄糖液 5 0 0ml加硝酸甘油 5～ 10mg静脉滴注 ,每天 1次 ,连用 14天。低分子量肝素组在常规治疗的基础上加用低分子量肝素(每毫升含低分子肝素钙 95 0 0IU) 0 .4～ 0 .6ml,每天 2次腹壁皮下注射 ,连用 10天。结果 :低分子量肝素组心绞痛发作次数及硝酸甘油含服量均有明显减少 ;心电图心肌缺血情况有明显改善 ,且无急性心肌梗死和猝死发生 ,与对照组差异均有显著性 (P <0 .0 0 1) ,且无出血副作用出现。结论 :低分子量肝素治疗不稳定型心绞痛安全可靠 。

Objective:To observe the curative effect and the side effect of low molecular weight heparin in treating unstable angina pectoris.Methods:Ninty eight patients suffering from unstable angina pectoris were randomly divided into low moleculer weight heparin group(Group A) and comparison group(Group B),then the curative effect was compared.Group B received routine treatment which includes nitrate\,β adrenoceptor blocking drugs,calcium channel blockers and 5% glucose add nitroglycerin 5 to 10 mg in intravenous drip every day for 14 days.Group A were given low molecular weight hepatin 0.4 to 0.6 ml hypodermic injection,twice a day in addition to the routine treatment,for 14 days.Results:Group A,both the times of angina attacks and the amount of nitroglycerine kept in the mouth were lessened obviously.Ischemis myocardial in ECG was improved obviously,and acute myocardial infarction(AMI) or cardiac death did not occur.Comparing with Group B,the difference was significant( P <0.001),and no bleeding occured.Conclusions:Low molecular weight heparin has a satisfactory curative effect in treatment of unstable angina pectoris.It is safe and credible.