CSF、血清S-100b蛋白水平的变化与开颅术后颅内感染的相关性研究

Correlation between changes of CSF and serum S-100b protein levels and intracranial infection after craniotomy

目的探讨开颅手术后颅内感染患者脑脊液(CSF)、血清中S-100b蛋白水平的变化及其临床意义。方法选取郑州大学附属洛阳中心医院行确诊的41例开颅术后并发颅内感染患者(2014年1月至2015年12月)作为感染组,82例开颅术后未出现颅内感染的患者作为对照组,检测并比较感染组和非感染组CSF、血清中S-100b蛋白等指标的水平,并探讨其临床意义。结果感染组患者CSF中S-100b蛋白、神经元特异性烯醇化酶(NSE)、肿瘤坏死因子-α(TNF-α)的水平均高于对照组(P<0.05);感染组患者血清中S-100b蛋白、C反应蛋白(CRP)、白细胞介素-10(IL-10)、TNF-α的水平均高于对照组(P<0.05);感染组患者血清中S-100b蛋白与CRP、IL-10、TNF-α呈显著的正相关性(r值分别为0.561、0.559、0.682,P<0.05);感染组患者CSF中S-100b蛋白与NSE、TNF-α的水平呈显著的正相关关系(r值分别为0.669、0.517,P<0.05)。结论开颅手术后颅内感染患者CSF、血清中S-100b蛋白早期即升高明显,并且与其他炎性指标具有良好的相关性。

Objective The changes and clinical significance of S-100 b protein in cerebrospinal fluid（ CSF） and serum in patients with intracranial infection after craniotomy were studied. Methods A total of41 cases of intracranial infection after craniotomy diagnosed in Luoyang Central Hospital Affiliated to Zhengzhou University from January 2014 to December 2015 were selected as infection group,and 82 cases without intracranial infection after craniotomy as control group. The CSF,serum S-100 b protein level and other indicators in infection group and non-infection group were detected and compared to explore the clinical significance. Results The levels of CSF,S-100 b,neuron specific enolase,and tumor necrosis factor-α in infection group were higher than those of the control group（ P 0. 05）; serum S-100 b protein,C reactive protein,tumor necrosis factor-α,and interleukin-10 were higher than those of control group（ P 0. 05）; the serum S-100 b protein in infection group was positively correlated with C reactive protein,tumor necrosis factor-α,and interleukin-10（ r = 0. 561,0,559,0. 682,P 0. 05）. There was a significant positive correlation between S-100 b in CSF and the expression of neuron specific enolase and tumor necrosis factor-αin infection group（ r = 0. 669,0. 517,P 0. 05）. Conclusion In post-craniotomy intracranial infection patients,CSF and serum S-100 b protein are increased significantly at early stage,and they have a good correlation with the other inflammatory indices.